Gene

sarm1

ID
ZDB-GENE-040219-1
Name
sterile alpha and TIR motif containing 1
Symbol
sarm1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Enables NAD+ nucleosidase activity. Involved in NAD+ catabolic process. Acts upstream of or within regulation of axon regeneration. Predicted to be located in axon; mitochondrion; and synapse. Predicted to be active in dendrite. Is expressed in posterior lateral line and spinal cord. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hzm13Allele with one delinsExon 1Frameshift, Premature StopCRISPR
hzm14Allele with one delinsExon 1Frameshift, Premature StopCRISPR
sa7407Allele with one point mutationUnknownMissenseENU
sa10409Allele with one point mutationUnknownPremature StopENU
sa11193Allele with one point mutationUnknownPremature StopENU
sa19119Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-sarm1 (4)
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Human Disease
Associated With sarm1 Human Ortholog
No data available
Associated With sarm1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR001660 Sterile alpha motif domain
Family IPR039184 Sterile alpha and TIR motif-containing protein 1
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Armadillo-like helical Armadillo-type fold Sterile alpha and TIR motif-containing protein 1 Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:F1QWA8 InterPro 713
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sarm1-201 (1) Ensembl 4,019 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-209M4ZFIN Curated Data
Contained inBACDKEY-234F12ZFIN Curated Data
EncodescDNAMGC:195078ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSARM117
Amino acid sequence comparison (4)
Conserved genome location (synteny) (1)
MouseSarm111
Amino acid sequence comparison (2)
Citations
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