Gene
sarm1
- ID
- ZDB-GENE-040219-1
- Name
- sterile alpha and TIR motif containing 1
- Symbol
- sarm1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables NAD+ nucleosidase activity. Involved in NAD+ catabolic process. Acts upstream of or within regulation of axon regeneration. Predicted to be located in axon; mitochondrion; and synapse. Predicted to be active in dendrite. Is expressed in posterior lateral line and spinal cord. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hzm13 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
hzm14 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
sa7407 | Allele with one point mutation | Unknown | Missense | ENU | |
sa10409 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11193 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19119 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
Domain | IPR001660 | Sterile alpha motif domain |
Family | IPR039184 | Sterile alpha and TIR motif-containing protein 1 |
Homologous_superfamily | IPR011989 | Armadillo-like helical |
Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Sterile alpha and TIR motif-containing protein 1 | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QWA8 | InterPro | 713 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-209M4 | ZFIN Curated Data | |
Contained in | BAC | DKEY-234F12 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195078 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001130596 (1) | 2542 nt | ||
Genomic | GenBank:BX663513 (2) | 249413 nt | ||
Polypeptide | UniProtKB:F1QWA8 (1) | 713 aa |
- Tuttle, A.M., Miller, L.N., Royer, L.J., Wen, H., Kelly, J.J., Calistri, N.L., Heiser, L.M., Nechiporuk, A.V. (2024) Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(16):
- Fazal, S.V., Mutschler, C., Chen, C.Z., Turmaine, M., Chen, C.Y., Hsueh, Y.P., Ibañez-Grau, A., Loreto, A., Casillas-Bajo, A., Cabedo, H., Franklin, R.J.M., Barker, R.A., Monk, K.R., Steventon, B.J., Coleman, M.P., Gomez-Sanchez, J.A., Arthur-Farraj, P. (2023) SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice. Frontiers in Cellular Neuroscience. 17:11583881158388
- Asgharsharghi, A., Tian, W., Haehnel-Taguchi, M., López-Schier, H. (2021) Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish. microPublication. Biology. 2021:
- Tang, H.P., Huang, C., Hu, C.B., Li, H., Shao, T., Ji, J.F., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2021) Inhibitory Role of an Aeromonas hydrophila TIR Domain Effector in Antibacterial Immunity by Targeting TLR Signaling Complexes in Zebrafish. Frontiers in microbiology. 12:694081
- Tian, W., Czopka, T., López-Schier, H. (2020) Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration. Communications biology. 3:49
- Tian, W., López-Schier, H. (2020) Blocking Wallerian degeneration by loss of Sarm1 does not promote axon resealing in zebrafish. microPublication. Biology. 2020
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Essuman, K., Summers, D.W., Sasaki, Y., Mao, X., DiAntonio, A., Milbrandt, J. (2017) The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration. Neuron. 93:1334-1343.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kanwal, Z., Zakrzewska, A., den Hertog, J., Spaink, H.P., Schaaf, M.J., and Meijer, A.H. (2013) Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 190(4):1631-1645
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