Gene

cdkn1ca

ID
ZDB-GENE-040123-1
Name
cyclin dependent kinase inhibitor 1Ca
Symbol
cdkn1ca Nomenclature History
Previous Names
  • cb961 (1)
  • cdkn1c
  • p21-like (1)
  • p27Xic1-a (1)
  • p57kip2 (1)
  • zgc:86618
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Acts upstream of or within cell fate specification; glial cell differentiation; and negative regulation of mitotic cell cycle. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; muscle; nervous system; neural tube; and notochord. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
51 figures from 36 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Osborn et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa38636Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-cdkn1caN/A (2)
MO2-cdkn1caN/A (3)
MO3-cdkn1caN/AOsborn et al., 2011
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Human Disease
Associated With cdkn1ca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Beckwith-Wiedemann syndrome Alliance Beckwith-Wiedemann syndrome 130650
IMAGe syndrome Alliance IMAGE syndrome 614732
1 - 2 of 2
Associated With cdkn1ca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003175 Cyclin-dependent kinase inhibitor domain
Homologous_superfamily IPR044898 Cyclin-dependent kinase inhibitor domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Cyclin-dependent kinase inhibitor domain Cyclin-dependent kinase inhibitor domain superfamily
UniProtKB:Q6IQT7 InterPro 212
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 7
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cdkn1ca-201 (1) Ensembl 1,566 nt
mRNA cdkn1ca-202 (1) Ensembl 1,953 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:cdkn1ca-FLAG)
  • Danio rerio
1 (2)
Tg(hsp70l:cdkn1ca-GFP,cryaa:Venus)
  • Danio rerio
Wei et al., 2023
Tg(hsp70l:cdkn1c-MYC)
  • cdkn1ca
  • Danio rerio
1 (4)
1 - 3 of 3
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-7P8ZFIN Curated Data
EncodesESTcb961Thisse et al., 2001
EncodescDNAMGC:86618ZFIN Curated Data
EncodescDNAMGC:173881ZFIN Curated Data
Is Hybridized bySTSchunp487
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCDKN1C11
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseCdkn1c7
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 71
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