Gene
insb
- ID
- ZDB-GENE-040113-2
- Name
- preproinsulin b
- Symbol
- insb Nomenclature History
- Previous Names
-
- zfins2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity and insulin receptor binding activity. Predicted to be involved in glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastomere; dermal bone; digestive system; kidney; and shield. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns295 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| la018929Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-insb | Mullapudi et al., 2018 | |
| MO1-insb | N/A | Shimada et al., 2012 |
| MO2-insb | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin | Insulin, conserved site | Insulin-like | Insulin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A140LFX1 | InterPro | 151 | ||||
| UniProtKB:A0A8M6Z2M5 | InterPro | 167 | ||||
| UniProtKB:Q2QAJ9 | InterPro | 107 | ||||
| UniProtKB:A0AB32T7F9 | InterPro | 159 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ins:TagRFPT-2A-insb) |
| 1 | Mullapudi et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18F5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194095 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194123 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039064 (1) | 498 nt | ||
| Genomic | GenBank:BX088535 (1) | 197465 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z2M5 (1) | 167 aa |
No data available
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Chen, Y., Jia, J., Zhao, Q., Zhang, Y., Huang, B., Wang, L., Tian, J., Huang, C., Li, M., Li, X. (2022) Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress. International Journal of Molecular Sciences. 23(21):
- Tang, L., Li, J., Sun, B., Bai, Y., Zhou, X., Chen, L. (2022) Transcriptomic Interaction between Young Fecal Transplantation and Perfluorobutanesulfonate in Aged Zebrafish Gonads. Toxics. 10(11):
- Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631
- Yang, L., Webb, S.E., Jin, N., Lee, H.M., Chan, T.F., Xu, G., Chan, J.C.N., Miller, A.L., Ma, R.C.W. (2021) Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Journal of diabetes investigation. 12(5):710-727
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698
- Eskova, A., Frohnhöfer, H.G., Nüsslein-Volhard, C., Irion, U. (2019) Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish. Current biology : CB. 30(2):298-303.e3
- Tu, W., Mart Iacute Nez L Oacute Pez, R.E.N.F., Navarro-Martin, L., Kostyniuk, D.J., Hum, C., Huang, J., Deng, M., Jin, Y., Chan, H.M., Mennigen, J. (2019) Bioconcentration and metabolic effects of emerging PFOS alternatives in developing zebrafish. Environmental science & technology. 53(22):13427-13439
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