Gene
insb
- ID
- ZDB-GENE-040113-2
- Name
- preproinsulin b
- Symbol
- insb Nomenclature History
- Previous Names
-
- zfins2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity and insulin receptor binding activity. Predicted to be involved in glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastomere; dermal bone; digestive system; kidney; and shield. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin | Insulin, conserved site | Insulin-like | Insulin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A140LFX1 | InterPro | 151 | ||||
| UniProtKB:A0A8M6Z2M5 | InterPro | 167 | ||||
| UniProtKB:Q2QAJ9 | InterPro | 107 | ||||
| UniProtKB:A0AB32T7F9 | InterPro | 159 |
Interactions and Pathways
Plasmids
No data available