Gene
scap
- ID
- ZDB-GENE-040107-41
- Name
- SREBF chaperone
- Symbol
- scap Nomenclature History
- Previous Names
-
- si:dkey-201i6.4
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable sterol binding activity. Acts upstream of or within lipid metabolic process and lipid storage. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum. Predicted to be part of SREBP-SCAP complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SCAP (SREBF chaperone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa484 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-scap | N/A | Schlombs et al., 2003 |
| MO2-scap | N/A | (5) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR000731 | Sterol-sensing domain |
| Domain | IPR053958 | HMGCR/SNAP/NPC1-like, sterol-sensing domain |
| Family | IPR030225 | Sterol regulatory element-binding protein cleavage-activating protein |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | HMGCR/SNAP/NPC1-like, sterol-sensing domain | Sterol regulatory element-binding protein cleavage-activating protein | Sterol-sensing domain | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B4M5 | InterPro | 1294 | |||||||
| UniProtKB:E9QEH6 | InterPro | 1245 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-201I6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_681493 (1) | 8820 nt | ||
| Genomic | GenBank:BX511123 (2) | 159464 nt | ||
| Polypeptide | UniProtKB:A0A8M2B4M5 (1) | 1294 aa |
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Zhang, C., Ellis, J.L., Yin, C. (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Disease models & mechanisms. 9(11):1383-1396
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Falcinelli, S., Picchietti, S., Rodiles, A., Cossignani, L., Merrifield, D.L., Taddei, A.R., Maradonna, F., Olivotto, I., Gioacchini, G., Carnevali, O. (2015) Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism. Scientific Reports. 5:9336
- Howarth, D.L., Lindtner, C., Vacaru, A.M., Sachidanandam, R., Tsedensodnom, O., Vasilkova, T., Buettner, C., Sadler, K.C. (2014) Activating transcription factor 6 is necessary and sufficient for alcoholic Fatty liver disease in zebrafish. PLoS Genetics. 10:e1004335
- Howarth, D.L., Yin, C., Yeh, K., and Sadler, K.C. (2013) Defining hepatic dysfunction parameters in two models of Fatty liver disease in zebrafish larvae. Zebrafish. 10(2):199-210
- Piccinetti, C.C., Migliarini, B., Olivotto, I., Simoniello, M.P., Giorgini, E., and Carnevali, O. (2013) Melatonin and Peripheral Circuitries: Insights on Appetite and Metabolism in Danio Rerio. Zebrafish. 10(3):275-82
- Cinaroglu, A., Gao, C., Imrie, D., and Sadler, K.C. (2011) Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. Hepatology (Baltimore, Md.). 54(2):495-508
- Passeri, M.J., Cinaroglu, A., Gao, C., and Sadler, K.C. (2009) Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology (Baltimore, Md.). 49(2):443-452
- Schlombs, K., Wagner, T., and Scheel, J. (2003) Site-1 protease is required for cartilage development in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 100(24):14024-14029
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