Gene
figla
- ID
- ZDB-GENE-031121-1
- Name
- folliculogenesis specific bHLH transcription factor
- Symbol
- figla Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within female gonad development. Predicted to be located in nucleus. Is expressed in gonad; male organism; ovary; and testis. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 6. Orthologous to human FIGLA (folliculogenesis specific bHLH transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109752 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Qin et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| umo14 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 6 | Alliance | Premature ovarian failure 6 | 612310 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q568W8 | InterPro | 220 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-367H4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109752 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191492 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198919 (1) | 1140 nt | ||
| Genomic | GenBank:CU896567 (2) | 116731 nt | ||
| Polypeptide | UniProtKB:Q568W8 (1) | 220 aa |
- Ahmad, A., Bogoch, Y., Shvaizer, G., Guler, N., Levy, K., Elkouby, Y.M. (2025) The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules. PLoS Genetics. 21:e1010868e1010868
- Wu, K., Zhai, Y., Qin, M., Zhao, C., Ai, N., He, J., Ge, W. (2023) Genetic evidence for differential functions of figla and nobox in zebrafish ovarian differentiation and folliculogenesis. Communications biology. 6:11851185
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Qin, M., Xie, Q., Wu, K., Zhou, X., Ge, W. (2022) Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish. Biology of reproduction. 106(6):1254-1266
- King, A.C., Gut, M., Zenker, A.K. (2020) Shedding new light on early sex determination in zebrafish. Archives of toxicology. 94(12):4143-4158
- Zhang, Q., Ye, D., Wang, H., Wang, Y., Sun, Y. (2020) Zebrafish cyp11c1 knockout reveals the roles of 11-ketotestosterone and cortisol in sexual development and reproduction. Endocrinology. 161(6):
- Hou, L.P., Chen, H., Tian, C.E., Shi, W.J., Liang, Y., Wu, R.R., Fang, X.W., Zhang, C.P., Liang, Y.Q., Xie, L. (2018) The progestin norethindrone affects sex differentiation and alters transcriptional profiles of genes along the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in juvenile zebrafish Dario renio. Aquatic toxicology (Amsterdam, Netherlands). 201:31-39
- Qin, M., Zhang, Z., Song, W., Wong, Q.W., Chen, W., Shirgaonkar, N., Ge, W. (2018) Roles of Figla/figla in Juvenile Ovary Development and Follicle Formation during Zebrafish Gonadogenesis. Endocrinology. 159(11):3699-3722
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
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