Gene
rab5c
- ID
- ZDB-GENE-031118-30
- Name
- RAB5C, member RAS oncogene family
- Symbol
- rab5c Nomenclature History
- Previous Names
-
- wu:fb98b08
- wu:fi16g01
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Involved in hematopoietic stem cell proliferation. Acts upstream of or within several processes, including endothelial tip cell filopodium assembly; regulation of cell migration involved in sprouting angiogenesis; and regulation of signal transduction. Located in early endosome. Is expressed in axial vasculature; blood; and intermediate cell mass of mesoderm. Orthologous to human RAB5C (RAB5C, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143044 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ioz111 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la023931Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mu229 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa44559 | Allele with one point mutation | Unknown | Unknown | ENU |
1 - 4 of 4
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rab5c | (2) | |
| CRISPR2-rab5c | Kempers et al., 2021 | |
| MO1-rab5c | N/A | (5) |
| MO2-rab5c | N/A | Kalén et al., 2009 |
| MO3-rab5c | N/A | (2) |
| MO4-rab5c | N/A | Heng et al., 2020 |
1 - 6 of 6
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTP-binding domain |
|---|---|---|---|---|---|
| UniProtKB:Q7ZVP2 | InterPro | 221 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:EGFP-rab5c) |
|
| 1 | Otis et al., 2019 | |
| Tg(actb2:mCherry-rab5c) |
|
| 1 | (2) | |
| Tg(h2ax:EGFP-rab5c) |
|
| 1 | (12) | |
| Tg(krt18a.1:rab5c-Venus) |
|
| 1 | Saitoh et al., 2017 | |
| Tg(mpeg1.1:rab5c-mCherry,myl7:EGFP) |
| 1 | Iyer et al., 2022 | ||
| Tg(UAS:mCherry-rab5c_Q81L) |
|
| 1 | (5) | |
| Tg(UAS:mCherry-rab5c_S36N) |
|
| 1 | (6) |
1 - 7 of 7
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-210G13 | ZFIN Curated Data | |
| Encodes | EST | fb98b08 | ||
| Encodes | EST | fi16g01 | ||
| Encodes | EST | IMAGE:7143044 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55826 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77261 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192222 | ZFIN Curated Data |
1 - 7 of 7
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201501 (1) | 2268 nt | ||
| Genomic | GenBank:BX005093 (1) | 155392 nt | ||
| Polypeptide | UniProtKB:Q7ZVP2 (1) | 221 aa |
- Liang, S., Zhou, Y., Chang, Y., Li, J., Zhang, M., Gao, P., Li, Q., Yu, H., Kawakami, K., Ma, J., Zhang, R. (2024) A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration. Cellular and molecular life sciences : CMLS. 81:158158
- Almeida, A.R., Macklin, W.B. (2023) Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate. eLIFE. 12:
- Koop, K., Yuan, W., Tessadori, F., Rodriguez-Polanco, W.R., Grubbs, J., Zhang, B., Osmond, M., Graham, G., Sawyer, S., Conboy, E., Vetrini, F., Treat, K., Płoski, R., Pienkowski, V.M., Kłosowska, A., Fieg, E., Krier, J., Mallebranche, C., Alban, Z., Aldinger, K.A., Ritter, D., Macnamara, E., Sullivan, B., Herriges, J., Alaimo, J.T., Helbig, C., Ellis, C.A., Eyk, C., Gecz, J., Farrugia, D., Osei-Owusu, I., Adès, L., Boogaard, M.J., Fuchs, S., Bakker, J., Duran, K., Dawson, Z.D., Lindsey, A., Huang, H., Baldridge, D., Silverman, G.A., Grant, B.D., Raizen, D., Network, U.D., Haaften, G., Pak, S.C., Rehmann, H., Schedl, T., van Hasselt, P. (2023) Macrocephaly and developmental delay caused by missense variants in RAB5C. Human molecular genetics. 32(21):3063-3077
- Iyer, H., Shen, K., Meireles, A.M., Talbot, W.S. (2022) A lysosomal regulatory circuit essential for the development and function of microglia. Science advances. 8:eabp8321
- Williams, D.M., Gungordu, L., Jackson-Crawford, A., Lowe, M. (2022) Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium. Journal of Cell Science. 135(18)
- Balaraju, A.K., Hu, B., Rodriguez, J.J., Murry, M., Lin, F. (2021) Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2. Development (Cambridge, England). 148(14):
- Clark, B.S., Miesfeld, J.B., Flinn, M.A., Collery, R.F., Link, B.A. (2021) Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis. Frontiers in cell and developmental biology. 8:608112
- Kempers, L., Wakayama, Y., van der Bijl, I., Furumaya, C., De Cuyper, I.M., Jongejan, A., Kat, M., van Stalborch, A.D., van Boxtel, A.L., Hubert, M., Geerts, D., van Buul, J.D., de Korte, D., Herzog, W., Margadant, C. (2021) The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis. Angiogenesis. 24(3):695-714
- Marsal, M., Hernández-Vega, A., Pouille, P.A., Martin-Blanco, E. (2021) Rab5ab-Mediated Yolk Cell Membrane Endocytosis Is Essential for Zebrafish Epiboly and Mechanical Equilibrium During Gastrulation. Frontiers in cell and developmental biology. 9:697097
- Bosze, B., Ono, Y., Mattes, B., Sinner, C., Gourain, V., Thumberger, T., Tlili, S., Wittbrodt, J., Saunders, T.E., Strähle, U., Schug, A., Scholpp, S. (2020) Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish. Histochemistry and cell biology. 154(5):463-480
1 - 10 of 44
Show