Gene
fen1
- ID
- ZDB-GENE-031112-11
- Name
- flap structure-specific endonuclease 1
- Symbol
- fen1 Nomenclature History
- Previous Names
-
- cb879 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and nuclease activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; head; pectoral fin musculature; and proliferative region. Orthologous to human FEN1 (flap structure-specific endonuclease 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb879 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5'-3' exonuclease, C-terminal domain superfamily | Flap endonuclease 1 | Helix-hairpin-helix motif, class 2 | PIN-like domain superfamily | XPG conserved site | XPG-I domain | XPG, N-terminal | XPG/Rad2 endonuclease |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TNU4 | InterPro | 380 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106
- Sun, J., Peterson, E.A., Wang, A.Z., Ou, J., Smith, K.E., Poss, K.D., Wang, J. (2022) hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Circulation. 146(1):48-63
- Lu, C., Luo, J., Liu, Y., Yang, X. (2020) The oxidative stress responses caused by phthalate acid esters increases mRNA abundance of base excision repair (BER) genes in vivo and in vitro. Ecotoxicology and environmental safety. 208:111525
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Chen, H., Wang, P., Du, Z., Wang, G., Gao, S. (2017) Oxidative stress, cell cycle arrest, DNA damage and apoptosis in adult zebrafish (Danio rerio) induced by tris(1,3-dichloro-2-propyl) phosphate. Aquatic toxicology (Amsterdam, Netherlands). 194:37-45
- Zheng, M., Lu, J., Zhao, D. (2017) Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. The Science of the total environment. 622-623:930-941
- Du, Z., Zhang, Y., Wang, G., Peng, J., Wang, Z., Gao, S. (2016) TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver. Scientific Reports. 6:21827
- Leontovich, A.A., Intine, R.V., Sarras, M.P. (2016) Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. 2016:2860780
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Bielczyk-Maczyńska, E., Serbanovic-Canic, J., Ferreira, L., Soranzo, N., Stemple, D.L., Ouwehand, W.H., Cvejic, A. (2014) A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. PLoS Genetics. 10:e1004450
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