Gene
dpysl2b
- ID
- ZDB-GENE-031105-1
- Name
- dihydropyrimidinase like 2b
- Symbol
- dpysl2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Acts upstream of or within neuron development; regulation of axonogenesis; and regulation of motor neuron migration. Located in cytosol. Is expressed in nervous system; neural plate; otic vesicle; spinal cord neural tube; and trigeminal placode. Orthologous to human DPYSL2 (dihydropyrimidinase like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011810Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017425Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa41632 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| wa21 | Allele with one delins | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dpysl2b | (2) | |
| MO1-dpysl2b | N/A | (4) |
| MO2-dpysl2b | N/A | Bräutigam et al., 2011 |
| MO3-dpysl2b | N/A | (7) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006680 | Amidohydrolase-related |
| Family | IPR011778 | Hydantoinase/dihydropyrimidinase |
| Family | IPR050378 | Metallo-dependent Hydrolases Superfamily |
| Homologous_superfamily | IPR011059 | Metal-dependent hydrolase, composite domain superfamily |
| Homologous_superfamily | IPR032466 | Metal-dependent hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Amidohydrolase-related | Hydantoinase/dihydropyrimidinase | Metal-dependent hydrolase | Metal-dependent hydrolase, composite domain superfamily | Metallo-dependent Hydrolases Superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q52PJ3 | InterPro | 573 | |||||
| UniProtKB:A0A8M2B1U6 | InterPro | 643 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dpysl2b-201
(1)
|
Ensembl | 2,087 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-136O4 | ZFIN Curated Data | |
| Contained in | BAC | CH211-217K11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158133 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020517 (1) | 2590 nt | ||
| Genomic | GenBank:AL928672 (1) | 187939 nt | ||
| Polypeptide | UniProtKB:A0A8M2B1U6 (1) | 643 aa |
- Li, S., Guo, Y., Takahashi, M., Suzuki, H., Kosaki, K., Ohshima, T. (2024) Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2. Developmental Neurobiology. 84(3):203-216
- Guo, Y., Oliveros, C.F., Ohshima, T. (2022) CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain. Developmental Neurobiology. 82(6):533-544
- Suzuki, H., Li, S., Tokutomi, T., Takeuchi, C., Takahashi, M., Yamada, M., Okuno, H., Miya, F., Takenouchi, T., Numabe, H., Kosaki, K., Ohshima, T. (2022) De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with intellectual disabilities and documentation of functional relevance through zebrafish rescue and cellular transfection experiments. Human molecular genetics. 31(24):4173-4182
- Carretero-Rodriguez, L., Guðjónsdóttir, R., Poparic, I., Reilly, M.L., Chol, M., Bianco, I.H., Chiapello, M., Feret, R., Deery, M.J., Guthrie, S. (2021) The Rac-GAP alpha2-chimaerin signals via CRMP2 and stathmins in the development of the ocular motor system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(31):6652-6672
- Fiallos-Oliveros, C., Ohshima, T. (2020) Dpysl2 (CRMP2) is required for the migration of facial branchiomotor neurons in the developing zebrafish embryo. The International journal of developmental biology. 64:479-484
- Liu, Z.Z., Zhu, J., Wang, C.L., Wang, X., Han, Y.Y., Liu, L.Y., Xu, H.A. (2018) CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity. 2018:8791304
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Lagman, D., Franzén, I.E., Eggert, J., Larhammar, D., Abalo, X.M. (2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evolutionary Biology. 16:124
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
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