Gene

dpysl2b

ID
ZDB-GENE-031105-1
Name
dihydropyrimidinase like 2b
Symbol
dpysl2b Nomenclature History
Previous Names
  • CRMP-2 (1)
  • CRMP2 (1)
  • dpysl2
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Acts upstream of or within neuron development; regulation of axonogenesis; and regulation of motor neuron migration. Located in cytosol. Is expressed in nervous system; neural plate; otic vesicle; spinal cord neural tube; and trigeminal placode. Orthologous to human DPYSL2 (dihydropyrimidinase like 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la011810TgTransgenic insertionUnknownUnknownDNA
la017425TgTransgenic insertionUnknownUnknownDNA
sa41632Allele with one point mutationUnknownSplice SiteENU
wa21Allele with one delinsExon 3UnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-dpysl2b (2)
MO1-dpysl2bN/A (4)
MO2-dpysl2bN/ABräutigam et al., 2011
MO3-dpysl2bN/A (7)
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Human Disease
Associated With dpysl2b Human Ortholog
No data available
Associated With dpysl2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006680 Amidohydrolase-related
Family IPR011778 Hydantoinase/dihydropyrimidinase
Family IPR050378 Metallo-dependent Hydrolases Superfamily
Homologous_superfamily IPR011059 Metal-dependent hydrolase, composite domain superfamily
Homologous_superfamily IPR032466 Metal-dependent hydrolase
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Domain Details Per Protein
Protein Additional Resources Length Amidohydrolase-related Hydantoinase/dihydropyrimidinase Metal-dependent hydrolase Metal-dependent hydrolase, composite domain superfamily Metallo-dependent Hydrolases Superfamily
UniProtKB:Q52PJ3 InterPro 573
UniProtKB:A0A8M2B1U6 InterPro 643
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 10
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dpysl2b-201 (1) Ensembl 2,087 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-136O4ZFIN Curated Data
Contained inBACCH211-217K11ZFIN Curated Data
EncodescDNAMGC:158133ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanDPYSL28
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseDpysl214
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 20
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