Gene
eif4a1a
- ID
- ZDB-GENE-031030-2
- Name
- eukaryotic translation initiation factor 4A1A
- Symbol
- eif4a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translational initiation. Is expressed in several structures, including immature eye; neural rod; neuromast; paraxial mesoderm; and somite. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2596Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la011382Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016053Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014014 | RNA helicase, DEAD-box type, Q motif |
| Domain | IPR044728 | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | DEAD/DEAH box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA helicase, DEAD-box type, Q motif |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q802C9 | InterPro | 406 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif4a1a-201
(1)
|
Ensembl | 2,370 nt | ||
| ncRNA |
eif4a1a-002
(1)
|
Ensembl | 1,004 nt | ||
| ncRNA |
eif4a1a-003
(1)
|
Ensembl | 677 nt | ||
| ncRNA |
eif4a1a-004
(1)
|
Ensembl | 382 nt | ||
| ncRNA |
eif4a1a-005
(1)
|
Ensembl | 883 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-62K3 | ZFIN Curated Data | |
| Contains | SNP | rs3728048 | ZFIN Curated Data | |
| Encodes | EST | fb20a10 | ZFIN Curated Data | |
| Encodes | EST | fb49a04 | ||
| Encodes | EST | fb71f03 | Rauch et al., 2003 | |
| Encodes | EST | fc76a02 | ZFIN Curated Data | |
| Encodes | EST | fc96c01 | ||
| Encodes | EST | fd15g03 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909894 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7143023 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198366 (1) | 2668 nt | ||
| Genomic | GenBank:CR848032 (1) | 125089 nt | ||
| Polypeptide | UniProtKB:Q802C9 (1) | 406 aa |
- Eghan, K., Lee, S., Yoo, D., Kim, W.K. (2025) 2-Ethylhexanol induces autism-like neurobehavior and neurodevelopmental disorders in zebrafish. Journal of hazardous materials. 488:137469137469
- Lescat, L., Véron, V., Mourot, B., Péron, S., Chenais, N., Dias, K., Riera, N., Beaumatin, F., Pinel, K., Priault, M., Panserat, S., Salin, B., Guiguen, Y., Bobe, J., Herpin, A., Seiliez, I. (2020) Chaperone-Mediated Autophagy in the light of evolution: insight from fish. Molecular Biology and Evolution. 37(10):2887-2899
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
- Jiang, L., Romero-Carvajal, A., Haug, J.S., Seidel, C.W., Piotrowski, T. (2014) Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 111:E1383-92
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Luo, D., Hu, W., Chen, S., Xiao, Y., Sun, Y., and Zhu, Z. (2009) Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Danio rerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization. Biology of reproduction. 80(4):674-684
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H., Kamachi, Y. (2006) Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(3):811-825
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