Gene
tp53inp1
- ID
- ZDB-GENE-031018-3
- Name
- tumor protein p53 inducible nuclear protein 1
- Symbol
- tp53inp1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to be involved in autophagosome assembly and positive regulation of DNA-templated transcription. Predicted to act upstream of or within autophagy. Predicted to be located in cytoplasmic vesicle; cytosol; and nuclear body. Predicted to be active in autophagosome and nucleus. Is expressed in nervous system and neural tube. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1036 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019778Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10505 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22919 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR029431 | Tumour protein p53-inducible nuclear protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Tumour protein p53-inducible nuclear protein |
|---|---|---|---|
| UniProtKB:A0PJS8 | InterPro | 241 | |
| UniProtKB:A8E5A5 | InterPro | 241 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tp53inp1-201
(1)
|
Ensembl | 1,587 nt | ||
| mRNA |
tp53inp1-202
(1)
|
Ensembl | 1,315 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-233C16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-233E16 | ZFIN Curated Data | |
| Encodes | EST | cb1036 | Thisse et al., 2001 | |
| Encodes | EST | fb70a09 | ||
| Encodes | EST | fi13h08 | ||
| Encodes | cDNA | MGC:158431 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174207 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080036 (1) | 1553 nt | ||
| Genomic | GenBank:BX004808 (1) | 184760 nt | ||
| Polypeptide | UniProtKB:A0PJS8 (1) | 241 aa |
- Ren, Y., Wang, C., Wang, H., Chang, Q., Guo, D., Wang, X. (2022) Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein. Fish & shellfish immunology. 127:925-932
- de Peralta, M.S., Mouguelar, V.S., Sdrigotti, M.A., Ishiy, F.A., Fanganiello, R.D., Passos-Bueno, M.R., Coux, G., Calcaterra, N.B. (2016) Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes. Cell Death & Disease. 7:e2397
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Satija, R., Farrell, J.A., Gennert, D., Schier, A.F., Regev, A. (2015) Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol.. 33(5):495-502
- Wei, L., Hoole, D., and Sun, B. (2014) Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver. Toxicology and industrial health. 4(2):62-68
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Pujic, Z., Omori, Y., Tsujikawa, M., Thisse, B., Thisse, C., and Malicki, J. (2006) Reverse genetic analysis of neurogenesis in the zebrafish retina. Developmental Biology. 293(2):330-347
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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