Gene
stmn1a
- ID
- ZDB-GENE-031006-14
- Name
- stathmin 1a
- Symbol
- stmn1a Nomenclature History
- Previous Names
-
- stmn1
- cb959 (1)
- wu:fb14e04
- zgc:136942
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable tubulin binding activity. Predicted to be involved in microtubule depolymerization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in microtubule. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including digestive system; nervous system; pectoral fin bud; tail bud; and ventral mesoderm. Orthologous to human STMN1 (stathmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb959 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028000Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-stmn1a | N/A | Carretero-Rodriguez et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Stathmin, conserved site | Stathmin family | Stathmin superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q1RLQ1 | InterPro | 148 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
stmn1a-202
(1)
|
Ensembl | 839 nt | ||
| mRNA |
stmn1a-201
(1)
|
Ensembl | 1,083 nt | ||
| mRNA |
stmn1a-203
(1)
|
Ensembl | 221 nt | ||
| mRNA |
stmn1a-204
(1)
|
Ensembl | 3,914 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-30B16 | ZFIN Curated Data | |
| Encodes | EST | cb959 | Thisse et al., 2001 | |
| Encodes | EST | fb14e04 | ||
| Encodes | cDNA | MGC:136942 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040375 (1) | 956 nt | ||
| Genomic | GenBank:CR925717 (2) | 103832 nt | ||
| Polypeptide | UniProtKB:Q1RLQ1 (1) | 148 aa |
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Carretero-Rodriguez, L., Guðjónsdóttir, R., Poparic, I., Reilly, M.L., Chol, M., Bianco, I.H., Chiapello, M., Feret, R., Deery, M.J., Guthrie, S. (2021) The Rac-GAP alpha2-chimaerin signals via CRMP2 and stathmins in the development of the ocular motor system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(31):6652-6672
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Ma, D., Tu, C., Sheng, Q., Yang, Y., Kan, Z., Guo, Y., Shyr, Y., Scott, I.C., Lou, X. (2018) Dynamics of zebrafish heart regeneration using an HPLC-ESI-MS/MS approach. Journal of Proteome Research. 17(3):1300-1308
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
- Liu, Q., Klingler, R.H., Wimpee, B., Dellinger, M., King-Heiden, T., Grzybowski, J., Gerstenberger, S.L., Weber, D.N., Caravan, M.J. (2016) Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:272-282
- Yuan, Y., Zhang, J., Zhou, Q. (2016) Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43:99-102
- Beauchemin, M., Smith, A., Yin, V.P. (2015) Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration. Development (Cambridge, England). 142:4026-37
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