Gene
rpa1
- ID
- ZDB-GENE-030912-3
- Name
- replication protein A1
- Symbol
- rpa1 Nomenclature History
- Previous Names
-
- wu:fi14b08
- zgc:55337
- zgc:77092 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable damaged DNA binding activity and single-stranded telomeric DNA binding activity. Acts upstream of or within heart development. Predicted to be located in nucleus. Predicted to be part of DNA replication factor A complex. Is expressed in head and pectoral fin. Orthologous to human RPA1 (replication protein A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55337 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2618Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi2877bTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la010246Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019268Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2803 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6 | 619767 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
| Domain | IPR007199 | Replication factor-A protein 1, N-terminal |
| Domain | IPR013955 | Replication factor A, C-terminal |
| Domain | IPR031657 | Replication protein A, OB domain |
| Domain | IPR047192 | Replication factor A, C-terminal, eukaryotes |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleic acid-binding, OB-fold | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | Replication factor A, C-terminal | Replication factor A, C-terminal, eukaryotes | Replication factor A protein 1 | Replication factor-A protein 1, N-terminal | Replication protein A, OB domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NY74 | InterPro | 601 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-297D15 | ZFIN Curated Data | |
| Encodes | EST | fi14b08 | ||
| Encodes | cDNA | MGC:55337 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77092 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199811 (1) | 2490 nt | ||
| Genomic | GenBank:CU861670 (2) | 128333 nt | ||
| Polypeptide | UniProtKB:Q6NY74 (1) | 601 aa |
- Bian, W.P., Chen, Y., Luo, J., Wang, C., Xie, S., Pei, D. (2019) A knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system. ACS synthetic biology. 8(4):621-632
- Kamstra, J.H., Hurem, S., Martin, L.M., Lindeman, L.C., Legler, J., Oughton, D., Salbu, B., Brede, D.A., Lyche, J.L., Aleström, P. (2018) Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Scientific Reports. 8:15373
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
- Xia, H., Zhong, C., Wu, X., Chen, J., Tao, B., Xia, X., Shi, M., Zhu, Z., Trudeau, V.L., Hu, W. (2017) Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.. Genetics. 208(2):729-743
- Anderson, N.M., Li, D., Peng, H.L., Laroche, F.J., Mansour, M.R., Gjini, E., Aioub, M., Helman, D.J., Roderick, J.E., Cheng, T., Harrold, I., Samaha, Y., Meng, L., Amsterdam, A., Neuberg, D.S., Denton, T.T., Sanda, T., Kelliher, M.A., Singh, A., Look, A.T., Feng, H. (2016) The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 30(6):1365-74
- Leontovich, A.A., Intine, R.V., Sarras, M.P. (2016) Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. 2016:2860780
- Lončar, J., Popović, M., Krznar, P., Zaja, R., Smital, T. (2016) The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio). Scientific Reports. 6:28937
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Tiefenbach, J., Moll, P.R., Nelson, M.R., Hu, C., Baev, L., Kislinger, T., and Krause, H.M. (2010) A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. PLoS One. 5(3):e9797
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