Gene
hnrnpa1b
- ID
- ZDB-GENE-030912-14
- Name
- heterogeneous nuclear ribonucleoprotein A1b
- Symbol
- hnrnpa1b Nomenclature History
- Previous Names
-
- hnrnpa1
- hnrpa1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of protein-containing complex. Is expressed in brain; gut; retina; and trunk. Human ortholog(s) of this gene implicated in HTLV-1-associated myelopathy/tropical spastic paraparesis; amyotrophic lateral sclerosis type 20; distal myopathy 3; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909113 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa39423 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hnrnpa1b | (3) | |
| CRISPR2-hnrnpa1b | (2) | |
| MO1-hnrnpa1b | N/A | (2) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 20 | Alliance | Amyotrophic lateral sclerosis 20 | 615426 |
| distal myopathy 3 | Alliance | ?Myopathy, distal, 3 | 610099 |
| inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 | Alliance | ?Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3 | 615424 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | hnRNP A1, RNA recognition motif 1 | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q803K3 | InterPro | 422 | ||||
| UniProtKB:A0A8M1PGI6 | InterPro | 403 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
hnrnpa1b-202
(1)
|
Ensembl | 1,005 nt | ||
| mRNA |
hnrnpa1b-201
(1)
|
Ensembl | 1,564 nt | ||
| mRNA |
hnrnpa1b-203
(1)
|
Ensembl | 620 nt | ||
| mRNA |
hnrnpa1b-204
(1)
|
Ensembl | 473 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-174K1 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909113 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55638 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:56623 |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200104 (1) | 1583 nt | ||
| Genomic | GenBank:BX571773 (1) | 135439 nt | ||
| Polypeptide | UniProtKB:Q803K3 (1) | 422 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Vejnar, C.E., Abdelmessih, M., Takacs, C., Yartseva, V., Oikonomou, P., Christiano, R., Stoeckius, M., Lau, S., Lee, M., Beaudoin, J.D., Musaev, D., Darwich-Codore, H., Walther, T., Tavazoie, S., Cifuentes, D., Giraldez, A. (2019) Genome wide analysis of 3'-UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Genome research. 29(7):1100-1114
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Zhang, Y., O'Leary, M.N., Peri, S., Wang, M., Zha, J., Melov, S., Kappes, D.J., Feng, Q., Rhodes, J., Amieux, P.S., Morris, D.R., Kennedy, B.K., Wiest, D.L. (2017) Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Reports. 18:545-556
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show