Gene
vax1
- ID
- ZDB-GENE-030904-9
- Name
- ventral anterior homeobox 1
- Symbol
- vax1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including camera-type eye morphogenesis; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of retinal ganglion cell axon guidance. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural rod; eye; forebrain; forebrain neural keel; and optic vesicle. Human ortholog(s) of this gene implicated in syndromic microphthalmia 11. Orthologous to human VAX1 (ventral anterior homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77277 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42915 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic microphthalmia 11 | Alliance | ?Microphthalmia, syndromic 11 | 614402 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EMX/VAX/Noto Homeobox Transcription Factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4I9B5 | InterPro | 317 | |||||
| UniProtKB:Q801E0 | InterPro | 317 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-36G21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77277 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194410 (1) | 2577 nt | ||
| Genomic | GenBank:BX927351 (1) | 180081 nt | ||
| Polypeptide | UniProtKB:A0A0R4I9B5 (1) | 317 aa |
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- George, A., Lee, J., Liu, J., Kim, S., Brooks, B.P. (2022) Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(4):495-509
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Richardson, R., Owen, N., Toms, M., Young, R.M., Tracey-White, D., Moosajee, M. (2019) Transcriptome profiling of zebrafish optic fissure fusion. Scientific Reports. 9:1541
- Urasaki, A., Morishita, S., Naka, K., Uozumi, M., Abe, K., Huang, L., Watase, E., Nakagawa, O., Kawakami, K., Matsui, T., Bessho, Y., Inagaki, N. (2019) Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system. Scientific Reports. 9:12156
- Hehr, C.L., Halabi, R., McFarlane, S. (2018) Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. Cell adhesion & migration. 12(5):489-502
- Hauptmann, G., Lauter, G., Söll, I. (2016) Detection and signal amplification in Zebrafish RNA FISH. Methods (San Diego, Calif.). 98:50-9
- Samuel, A., Rubinstein, A.M., Azar, T.T., Ben-Moshe Livne, Z., Kim, S.H., Inbal, A. (2016) Six3 regulates optic nerve development via multiple mechanisms. Scientific Reports. 6:20267
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
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