Gene
nr1i2
- ID
- ZDB-GENE-030903-3
- Name
- nuclear receptor subfamily 1, group I, member 2
- Symbol
- nr1i2 Nomenclature History
- Previous Names
-
- PXR (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables nuclear steroid receptor activity. Acts upstream of or within regulation of DNA-templated transcription; response to toxic substance; and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adenohypophyseal placode; brain; heart; liver; and pleuroperitoneal region. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- af502918 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb871 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| la027133Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1903 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sib3 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sib4 | Allele with one delins | Unknown | Unknown | CRISPR | |
| wh1 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| wh2 | Allele with one delins | Unknown | Exon Loss, Frameshift, Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QAV5 | InterPro | 417 | ||||||
| UniProtKB:A5WYG8 | InterPro | 430 | ||||||
| UniProtKB:B0V1H8 | InterPro | 430 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-265I7 | ZFIN Curated Data | |
| Encodes | EST | af502918 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098617 (1) | 2475 nt | ||
| Genomic | GenBank:CR848676 (2) | 96536 nt | ||
| Polypeptide | UniProtKB:A5WYG8 (1) | 430 aa |
- Erradhouani, C., Piccini, B., Maillot-Marechal, E., Aït-Aïssa, S., Balaguer, P., Coumoul, X., Brion, F. (2025) New insights into the regulation of cyp3a65 expression in transgenic tg(cyp3a65:GFP) zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 279:107250107250
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Chen, S., Lathrop, K.L., Kuwajima, T., Gross, J.M. (2021) Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retina. Development (Cambridge, England). 149(8):
- Creusot, N., Garoche, C., Grimaldi, M., Boulahtouf, A., Chiavarina, B., Bourguet, W., Balaguer, P. (2021) A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays. Frontiers in endocrinology. 12:665521
- Leach, L.L., Hanovice, N.J., George, S.M., Gabriel, A.E., Gross, J.M. (2021) The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration. Proceedings of the National Academy of Sciences of the United States of America. 118(21)
- Wang, Y., Shen, D., Ullah, N., Diaby, M., Gao, B., Song, C. (2021) Characterization and expression pattern of ZB and PS transposons in zebrafish. Gene expression patterns : GEP. 42:119203
- Creusot, N., Gassiot, M., Alaterre, E., Chiavarina, B., Grimaldi, M., Boulahtouf, A., Toporova, L., Gerbal-Chaloin, S., Daujat-Chavanieu, M., Matheux, A., Rahmani, R., Gongora, C., Evrard, A., Pourquier, P., Balaguer, P. (2020) The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor. Cells. 9(7):
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
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