Gene
cadps2
- ID
- ZDB-GENE-030903-1
- Name
- Ca++-dependent secretion activator 2
- Symbol
- cadps2 Nomenclature History
- Previous Names
-
- cpd2 (1)
- zgc:110135
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity. Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to act upstream of or within dense core granule exocytosis and synaptic vesicle exocytosis. Predicted to be located in endomembrane system and synapse. Predicted to be active in glutamatergic synapse. Is expressed in hatching gland; nervous system; otic vesicle; pronephric duct; and trigeminal placode. Orthologous to human CADPS2 (calcium dependent secretion activator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110135 (12 images)
- eu166 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014721Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014722Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023268Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023271Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6001 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12715 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24694 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24695 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25229 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | Calcium-dependent secretion activator | Munc13 homology 1 | MUN domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PTA0 | InterPro | 483 | ||||
| UniProtKB:F1RCG6 | InterPro | 396 | ||||
| UniProtKB:A0A8M9PVK9 | InterPro | 1128 | ||||
| UniProtKB:A0AB32TK56 | InterPro | 1166 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
cadps2-203
(1)
|
Ensembl | 539 nt | ||
| mRNA |
cadps2-201
(1)
|
Ensembl | 1,618 nt | ||
| mRNA |
cadps2-202
(1)
|
Ensembl | 2,572 nt | ||
| mRNA |
cadps2-204
(1)
|
Ensembl | 769 nt | ||
| mRNA |
cadps2-205
(1)
|
Ensembl | 1,811 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-71G21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-142M8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-245M13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-1P18 | ZFIN Curated Data | |
| Encodes | EST | eu166 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:110135 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020491 (1) | 1649 nt | ||
| Genomic | GenBank:CR752641 (1) | 238675 nt | ||
| Polypeptide | UniProtKB:A0AB32TK56 (1) | 1166 aa |
- Wang, G.T., Pan, H.Y., Lang, W.H., Yu, Y.D., Hsieh, C.H., Kuan, Y.S. (2021) Three-dimensional multi-gene expression maps reveal cell fate changes associated with laterality reversal of zebrafish habenula. Journal of neuroscience research. 99(6):1632-1645
- Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N. (2018) Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of neuroendocrinology. 30(4):e12586
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Dean, B.J., Erdogan, B., Gamse, J.T., Wu, S.Y. (2014) Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Development. 9:20
- Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27
- Wu, S.Y., de Borsetti, N.H., Bain, E.J., Bulow, C.R., and Gamse, J.T. (2014) Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Developmental Biology. 385(1):13-22
- Colombo, A., Palma, K., Armijo, L., Mione, M., Signore, I.A., Morales, C., Guerrero, N., Meynard, M.M., Pérez, R., Suazo, J., Marcelain, K., Briones, L., Härtel, S., Wilson, S.W., and Concha, M.L. (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development (Cambridge, England). 140(19):3997-4007
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- de Borsetti, N.H., Dean, B.J., Bain, E.J., Clanton, J.A., Taylor, R.W., and Gamse, J.T. (2011) Light and melatonin schedule neuronal differentiation in the habenular nuclei. Developmental Biology. 358(1):251-61
- Matos-Cruz, V., Blasic, J., Nickle, B., Robinson, P.R., Hattar, S., and Halpern, M.E. (2011) Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PLoS One. 6(9):e25111
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