Gene
ada2a
- ID
- ZDB-GENE-030902-4
- Name
- adenosine deaminase 2a
- Symbol
- ada2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including adenosine deaminase activity; proteoglycan binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55247 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hg141 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la023164Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa38038 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44262 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ada2a | Brix et al., 2024 | |
| CRISPR2-ada2a | Brix et al., 2024 | |
| MO1-ada2a | N/A | Gessler et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sneddon syndrome | Alliance | Sneddon syndrome | 182410 |
| Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome | 615688 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenosine/adenine deaminase | Adenosine/AMP deaminase N-terminal | Adenosine deaminase domain | Adenosine deaminase-related growth factor | Metal-dependent hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:P58781 | InterPro | 503 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-276C7 | ZFIN Curated Data | |
| Encodes | EST | fj65e02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55247 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001033717 (1) | 2505 nt | ||
| Genomic | GenBank:BX004976 (1) | 151137 nt | ||
| Polypeptide | UniProtKB:P58781 (1) | 503 aa |
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Gessler, S., Guthmann, C., Schuler, V., Lilienkamp, M., Walz, G., Yakulov, T.A. (2022) Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling. International Journal of Molecular Sciences. 23(14):
- Cruz, F.F., Pereira, T.C.B., Altenhofen, S., da Costa, K.M., Bogo, M.R., Bonan, C.D., Morrone, F.B. (2019) Characterization of the adenosinergic system in a zebrafish embryo radiotherapy model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 224:108572
- Rico, E.P., Rosemberg, D.B., Berteli, J.F.A., da Silveira Langoni, A., Souto, A.A., Bogo, M.R., Bonan, C.D., Souza, D.O. (2018) Adenosine deaminase activity and gene expression patterns are altered after chronic ethanol exposure in zebrafish brain. Neurotoxicology and teratology. 65:14-18
- Altenhofen, S., Nabinger, D.D., Pereira, T.C.B., Leite, C.E., Bogo, M.R., Bonan, C.D. (2017) Manganese(II) Chloride Alters Nucleotide and Nucleoside Catabolism in Zebrafish (Danio rerio) Adult Brain. Molecular neurobiology. 55(5):3866-3874
- Zimmermann, F.F., Gaspary, K.V., Siebel, A.M., Leite, C.E., Kist, L.W., Bogo, M.R., Bonan, C.D. (2017) Analysis of Extracellular Nucleotide Metabolism in Adult Zebrafish After Embryological Exposure to Valproic Acid. Molecular neurobiology. 54(5):3542-3553
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Capiotti, K.M., Siebel, A.M., Kist, L.W., Bogo, M.R., Bonan, C.D., Da Silva, R.S. (2016) Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio). Purinergic signalling. 12(2):211-20
- Zimmermann, F.F., Altenhofen, S., Kist, L.W., Leite, C.E., Bogo, M.R., Cognato, G.P., Bonan, C.D. (2016) Unpredictable Chronic Stress Alters Adenosine Metabolism in Zebrafish Brain. Molecular neurobiology. 53(4):2518-28
- Altenhofen, S., Zimmermann, F.F., Barreto, L.S., Bortolotto, J.W., Kist, L.W., Bogo, M.R., Bonan, C.D. (2015) Benzodiazepines alter nucleotide and nucleoside hydrolysis in zebrafish (Danio rerio) brain. Journal of neural transmission (Vienna, Austria : 1996). 122(8):1077-88
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