Gene
e2f5
- ID
- ZDB-GENE-030828-3
- Name
- E2F transcription factor 5
- Symbol
- e2f5 Nomenclature History
- Previous Names
-
- cb735 (1)
- zgc:111879
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within female somatic sex determination; male meiosis I; and multi-ciliated epithelial cell differentiation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human E2F5 (E2F transcription factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb735 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ouc2019 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
ouc2020 | Allele with one insertion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
ouc2021 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
sq5716 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-e2f5 | Chong et al., 2018 | |
CRISPR2-e2f5 | Chong et al., 2018 | |
CRISPR3-e2f5 | Xie et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003316 | E2F/DP family, winged-helix DNA-binding domain |
Domain | IPR032198 | E2F transcription factor, CC-MB domain |
Family | IPR015633 | E2F Family |
Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | E2F/DP family, winged-helix DNA-binding domain | E2F-DP heterodimerization region | E2F Family | E2F transcription factor, CC-MB domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6TH18 | InterPro | 143 | ||||||
UniProtKB:A5WUE8 | InterPro | 363 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(actb2:EGFP-e2f5) |
|
| 1 | Xie et al., 2020 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-106H4 | ZFIN Curated Data | |
Encodes | EST | cb735 | Thisse et al., 2001 | |
Encodes | cDNA | MGC:111879 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001197300 (1) | 2340 nt | ||
Genomic | GenBank:CR293515 (2) | 192891 nt | ||
Polypeptide | UniProtKB:A5WUE8 (1) | 363 aa |
- Kang, Q., Zheng, J., Jia, J., Xu, Y., Bai, X., Chen, X., Zhang, X.K., Wong, F.S., Zhang, C., Li, M. (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. The Journal of biological chemistry. 298(12):102665
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Zhou, F., Rayamajhi, D., Ravi, V., Narasimhan, V., Chong, Y.L., Lu, H., Venkatesh, B., Roy, S. (2020) Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Developmental Biology. 465(2):168-177
- Kim, Y., Jeong, J., Lee, S., Choi, I., Choi, J. (2019) Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. Journal of hazardous materials. 388:121725
- Chong, Y.L., Zhang, Y., Zhou, F., Roy, S. (2018) Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Developmental Biology. 443(2):165-172
- Feng, S., Wang, S., Wang, Y., Yang, Q., Wang, D., Li, H. (2018) Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers. Gene expression patterns : GEP. 29:47-58
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Lam, S.H., Hlaing, M.M., Zhang, X., Yan, C., Duan, Z., Zhu, L., Ung, C.Y., Mathavan, S., Ong, C.N., and Gong, Z. (2011) Toxicogenomic and phenotypic analyses of bisphenol-a early-life exposure toxicity in zebrafish. PLoS One. 6(12):e28273
- Yang, Q., Hu, J., Ye, D., Zhao, C., Song, S., Gong, W., Tan, Z., and Song, P. (2010) Identification and expression analysis of two zebrafish E2F5 genes during oogenesis and development. Molecular biology reports. 37(4):1773-1780
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