Gene
hspa9
- ID
- ZDB-GENE-030828-12
- Name
- heat shock protein 9
- Symbol
- hspa9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within fin regeneration and hemopoiesis. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; eye; fin; midbrain; and segmental plate. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb740 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hi2473Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
hi3366Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
hspa9_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
sa45508 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant sideroblastic anemia 4 | Alliance | Anemia, sideroblastic, 4 | 182170 |
Even-plus syndrome | 616854 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
Family | IPR012725 | Chaperone DnaK |
Family | IPR013126 | Heat shock protein 70 family |
Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Chaperone DnaK | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q5XJ12 | InterPro | 682 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-194M19 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-87D10 | ZFIN Curated Data | |
Encodes | EST | cb740 | Thisse et al., 2001 | |
Encodes | EST | fc14d08 | ||
Encodes | EST | fc27c10 | ||
Encodes | EST | fc38a06 | ||
Encodes | cDNA | MGC:55454 | ZFIN Curated Data | |
Encodes | cDNA | MGC:86654 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191741 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201326 (1) | 3078 nt | ||
Genomic | GenBank:CR354536 (1) | 157228 nt | ||
Polypeptide | UniProtKB:Q5XJ12 (1) | 682 aa |
- Xiao, H., Li, M., Zhong, Y., Patel, A., Xu, R., Zhang, C., Athey, T.W., Fang, S., Xu, T., Du, S. (2025) Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70283e70283
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Cabezas-Sainz, P., Coppel, C., Pensado-López, A., Fernandez, P., Muinelo-Romay, L., López-López, R., Rubiolo, J.A., Sánchez, L. (2021) Morphological Abnormalities and Gene Expression Changes Caused by High Incubation Temperatures in Zebrafish Xenografts with Human Cancer Cells. Genes. 12(1):
- Lin, Y.F., Sam, J., Evans, T. (2021) Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response. iScience. 24:103118
- Mao, Y., Zong, Z., Dang, Y., Yu, L., Liu, C., Wang, J. (2021) Promotion effect of microcystin-LR on liver tumor progression in krasV12 transgenic zebrafish following acute or subacute exposure. Ecotoxicology and environmental safety. 224:112673
- Umali, J., Hawkey-Noble, A., French, C.R. (2019) Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer. Vision Research. 156:66-72
- Xu, K., Xu, H., Han, Z. (2018) Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Genes. 9(12)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, W.C., Wang, Z., Missinato, M.A., Park, D.W., Long, D.W., Liu, H.J., Zeng, X., Yates, N.A., Kim, K., Wang, Y. (2016) Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Science advances. 2:e1600844
- Silva, I. A. L., Conceição, N., Michou, L., Cancela, M. L. (2014) Can zebrafish be a valid model to study Paget's disease of bone?. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):678-688
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