Gene
hdr
- ID
- ZDB-GENE-030826-5
- Name
- hematopoietic death receptor
- Symbol
- hdr Nomenclature History
- Previous Names
-
- zgc:103531
- ZH-DR
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within positive regulation of apoptotic process. Located in plasma membrane. Is expressed in axis; hematopoietic system; mesoderm; and notochord.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103531 (12 images)
- eu245 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-hdr | N/A | Kwan et al., 2006 |
MO2-hdr | N/A | (2) |
MO3-hdr | N/A | Zhang et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000488 | Death domain |
Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
Domain | IPR034024 | Tumor necrosis factor receptor 10, N-terminal |
Domain | IPR034029 | Tumour necrosis factor receptor 10A/B, death domain |
Family | IPR052491 | Tumor necrosis factor receptor superfamily member 10 |
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Domain Details Per Protein
Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 10, N-terminal | Tumor necrosis factor receptor superfamily member 10 | Tumour necrosis factor receptor 10A/B, death domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q9DF34 | InterPro | 357 | ||||||
UniProtKB:F1QD95 | InterPro | 418 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEYP-38H2 | ZFIN Curated Data | |
Encodes | EST | eu245 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:103531 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192032 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_194391 (1) | 1451 nt | ||
Genomic | GenBank:BX323062 (1) | 199133 nt | ||
Polypeptide | UniProtKB:F1QD95 (1) | 418 aa |
No data available
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Wu, Y., Xia, Y., Li, P., Qu, H.Q., Liu, Y., Yang, Y., Lin, J., Zheng, M., Tian, L., Wu, Z., Huang, S., Qin, X., Zhou, X., Chen, S., Liu, Y., Wang, Y., Li, X., Zeng, H., Hakonarson, H., Zhuang, J. (2020) Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Orphanet journal of rare diseases. 15:101
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yi, Y., Qi, H., Yuan, J., Wang, R., Weng, S., He, J., Dong, C. (2015) Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome. Fish & shellfish immunology. 45(2):757-70
- Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
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