Gene
celf2
- ID
- ZDB-GENE-030826-35
- Name
- cugbp, Elav-like family member 2
- Symbol
- celf2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adaxial cell; immature eye; musculature system; nervous system; and neural plate. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF2 (CUGBP Elav-like family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb906 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa2160 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11849 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20283 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20284 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa26299 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa30851 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa33469 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38441 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
developmental and epileptic encephalopathy 97 | Alliance | Developmental and epileptic encephalopathy 97 | 619561 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | CELF1/2, RNA recognition motif 1 | CELF1/2, RNA recognition motif 2 | CELF1/2, RNA recognition motif 3 | Nucleotide-binding alpha-beta plait domain superfamily | Paraneoplastic encephalomyelitis antigen | RNA-binding domain superfamily | RNA recognition motif domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q097 | InterPro | 502 | |||||||
UniProtKB:A0A8M9QB14 | InterPro | 497 | |||||||
UniProtKB:A0A8M9Q087 | InterPro | 547 | |||||||
UniProtKB:A0A8M9QB04 | InterPro | 544 | |||||||
UniProtKB:A0A8M9PH22 | InterPro | 518 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-198D18 | ZFIN Curated Data | |
Encodes | EST | cb906 | Thisse et al., 2001 | |
Encodes | EST | fj87b07 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77203 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_194401 (1) | 1461 nt | ||
Genomic | GenBank:AL954688 (1) | 210027 nt | ||
Polypeptide | UniProtKB:A0A8M9PH27 (1) | 558 aa |
- Comparative Orthology
- Alliance
- Wang, D., Wang, X., Huang, H., Wang, H. (2021) Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Journal of hazardous materials. 413:125414
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Nikonova, E., Kao, S.Y., Ravichandran, K., Wittner, A., Spletter, M.L. (2019) Conserved functions of RNA-binding proteins in muscle. The international journal of biochemistry & cell biology. 110:29-49
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Choi, D.-K., Yoo, K.-W., Hong, S.-K., Rhee, M., Sakaki, Y., and Kim, C.-H. (2003) Isolation and expression of Napor/CUG-BP2 in embryo development. Biochemical and Biophysical Research Communications. 305(3):448-454
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Suzuki, H., Jin, Y., Otani, H., Yasuda, K., and Inoue, K. (2002) Regulation of alternative splicing of alpha-actinin transcript by Bruno-like proteins. Genes to cells : devoted to molecular & cellular mechanisms. 7(2):133-141
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