Gene

tpm3

ID
ZDB-GENE-030826-16
Name
tropomyosin 3
Symbol
tpm3 Nomenclature History
Previous Names
  • cb674 (1)
  • fa17b11
  • fb83b01
  • fk41e01
  • hm:zeh0298 (1)
  • wu:fa17b11 (1)
  • wu:fb83b01 (1)
  • wu:fk41e01 (1)
  • zeh0298
  • zgc:77592
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin filament. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Human ortholog(s) of this gene implicated in congenital myopathy 4A and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Bonnet et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ct5aGtTransgenic insertionUnknownUnknownDNA
la020572TgTransgenic insertionUnknownUnknownDNA
la020573TgTransgenic insertionUnknownUnknownDNA
la020574TgTransgenic insertionUnknownUnknownDNA
la020575TgTransgenic insertionUnknownUnknownDNA
sa9640Allele with one point mutationUnknownPremature StopENU
sa16993Allele with one point mutationUnknownPremature StopENU
sa23465Allele with one point mutationUnknownSplice SiteENU
sa36795Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With tpm3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myopathy 4A Alliance Congenital myopathy 4A, autosomal dominant 255310
nemaline myopathy 1 Alliance Congenital myopathy 4B, autosomal recessive 609284
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Associated With tpm3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000533 Tropomyosin
Homologous_superfamily IPR014751 DNA repair protein XRCC4-like, C-terminal
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Domain Details Per Protein
Protein Additional Resources Length DNA repair protein XRCC4-like, C-terminal Tropomyosin
UniProtKB:A0A8M2B6C5 InterPro 248
UniProtKB:A0A8M2B602 InterPro 284
UniProtKB:A0A2R8Q650 InterPro 284
UniProtKB:A0A8M2B695 InterPro 248
UniProtKB:I3ISQ1 InterPro 284
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tpm3-201 (1) Ensembl 2,501 nt
mRNA tpm3-202 (1) Ensembl 1,496 nt
mRNA tpm3-203 (1) Ensembl 386 nt
mRNA tpm3-204 (1) Ensembl 3,093 nt
mRNA tpm3-205 (1) Ensembl 5,073 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-240H12ZFIN Curated Data
Contained inFosmidCH1073-70F20ZFIN Curated Data
Contained inFosmidCH1073-127A7ZFIN Curated Data
ContainsSNPrs3728969
    ZFIN Curated Data
    ContainsSNPrs3728970
      ZFIN Curated Data
      EncodesESTcb674Thisse et al., 2001
      EncodesESTfa17b11
      EncodesESTfb80c04Rauch et al., 2003
      EncodesESTfb83b01
      EncodesESTfk41e01
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanTPM31
      Amino acid sequence comparison (1)
      Conserved genome location (synteny) (1)
      MouseTpm33
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (1)
      Citations
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