Gene
tpm3
- ID
- ZDB-GENE-030826-16
- Name
- tropomyosin 3
- Symbol
- tpm3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin filament. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Human ortholog(s) of this gene implicated in congenital myopathy 4A and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77592 (21 images)
- cb674 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Bonnet et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ct5aGt | Transgenic insertion | Unknown | Unknown | DNA | |
la020572Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la020573Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la020574Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la020575Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa9640 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16993 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa23465 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa36795 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-tpm3 | Bonnet et al., 2017 | |
MO1-tpm3 | N/A | Bonnet et al., 2017 |
MO2-tpm3 | N/A | Bonnet et al., 2017 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
congenital myopathy 4A | Alliance | Congenital myopathy 4A, autosomal dominant | 255310 |
nemaline myopathy 1 | Alliance | Congenital myopathy 4B, autosomal recessive | 609284 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
---|---|---|---|---|
UniProtKB:A0A8M2B6C5 | InterPro | 248 | ||
UniProtKB:A0A8M2B602 | InterPro | 284 | ||
UniProtKB:A0A2R8Q650 | InterPro | 284 | ||
UniProtKB:A0A8M2B695 | InterPro | 248 | ||
UniProtKB:I3ISQ1 | InterPro | 284 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-240H12 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-70F20 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-127A7 | ZFIN Curated Data | |
Contains | SNP | rs3728969 | ZFIN Curated Data | |
Contains | SNP | rs3728970 | ZFIN Curated Data | |
Encodes | EST | cb674 | Thisse et al., 2001 | |
Encodes | EST | fa17b11 | ||
Encodes | EST | fb80c04 | Rauch et al., 2003 | |
Encodes | EST | fb83b01 | ||
Encodes | EST | fk41e01 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201492 (1) | 2396 nt | ||
Genomic | GenBank:CT573147 (1) | 168801 nt | ||
Polypeptide | UniProtKB:A0A2R8Q650 (1) | 284 aa |
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Trivedi, V., Choi, H.M.T., Fraser, S.E., Pierce, N.A. (2018) Multidimensional quantitative analysis of mRNA expression within intact vertebrate embryos. Development (Cambridge, England). 145(1)
- Yan, Y., He, F., Li, Z., Xu, R., Li, T., Su, J., Liu, X., Zhao, M., Wu, W. (2018) The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis. Atherosclerosis. 280:99-108
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Bonnet, A., Lambert, G., Ernest, S., Dutrieux, F.X., Coulpier, F., Lemoine, S., Lobbardi, R., Rosa, F.M. (2017) Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin. Developmental Cell. 42(5):527-541.e4
- Dube, D.K., Dube, S., Abbott, L., Wang, J., Fan, Y., Alshiekh-Nasany, R., Shah, K.K., Rudloff, A.P., Poiesz, B.J., Sanger, J.M., Sanger, J.W. (2017) Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Cytoskeleton (Hoboken, N.J.). 74(3):125-142
- Dempsey, W.P., Hodas, N.O., Ponti, A., Pantazis, P. (2015) Determination of the source of SHG verniers in zebrafish skeletal muscle. Scientific Reports. 5:18119
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ruf-Zamojski, F., Trivedi, V., Fraser, S.E., Trinh, L.A. (2015) Spatio-Temporal Differences in Dystrophin Dynamics at mRNA and Protein Levels Revealed by a Novel FlipTrap Line. PLoS One. 10:e0128944
- Choi, H.M., Beck, V.A., Pierce, N.A. (2014) Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability. ACS nano. 8(5):4284-94
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