Gene
neurod4
- ID
- ZDB-GENE-030730-1
- Name
- neuronal differentiation 4
- Symbol
- neurod4 Nomenclature History
- Previous Names
-
- zath3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within several processes, including habenula development; neural plate morphogenesis; and olfactory placode development. Predicted to be active in nucleus. Is expressed in several structures, including head; nervous system; neural plate; neural tube; and trigeminal neural crest. Orthologous to human NEUROD4 (neuronal differentiation 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73042 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-neurod4 | (2) | |
| CRISPR2-neurod4 | (2) | |
| CRISPR3-neurod4 | (2) | |
| CRISPR4-neurod4 | (2) | |
| CRISPR5-neurod4 | (2) | |
| CRISPR6-neurod4 | (2) | |
| CRISPR7-neurod4 | (2) | |
| CRISPR8-neurod4 | (2) | |
| CRISPR9-neurod4 | Buono et al., 2021 | |
| CRISPR10-neurod4 | Buono et al., 2021 |
1 - 10 of 12
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR022575 | Neurogenic differentiation factor, domain of unknown function |
| Family | IPR016637 | Neurogenic differentiation factor NeuroD |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neurogenic differentiation factor, domain of unknown function | Neurogenic differentiation factor NeuroD |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QWM8 | InterPro | 348 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neurod4-201
(1)
|
Ensembl | 1,967 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-104L7 | ZFIN Curated Data | |
| Encodes | EST | fb17e09 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:73042 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86591 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_170762 (1) | 1966 nt | ||
| Genomic | GenBank:CR381567 (1) | 142417 nt | ||
| Polypeptide | UniProtKB:F1QWM8 (1) | 348 aa |
- Dicipulo, R., Selland, L.G., Carpenter, R.G., Waskiewicz, A.J. (2025) Functional role for Taz during hindbrain ventricle morphogenesis. PLoS One. 20:e0313262e0313262
- Cigliola, V., Shoffner, A., Lee, N., Ou, J., Gonzalez, T.J., Hoque, J., Becker, C.J., Han, Y., Shen, G., Faw, T.D., Abd-El-Barr, M.M., Varghese, S., Asokan, A., Poss, K.D. (2023) Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Nature communications. 14:48574857
- Leino, S.A., Constable, S.C.J., Streit, A., Wilkinson, D.G. (2023) Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. Development (Cambridge, England). 150(18):
- Shin, U., Choi, Y., Ko, H.S., Myung, K., Lee, S., Cheon, C.K., Lee, Y. (2023) A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Human genomics. 17:4444
- Veen, K., Krylov, A., Yu, S., He, J., Boyd, P., Hyde, D.R., Mantamadiotis, T., Cheng, L.Y., Jusuf, P.R. (2023) Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genetics. 19:e1011010e1011010
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Reuter, A.S., Stern, D., Bernard, A., Goossens, C., Lavergne, A., Flasse, L., Von Berg, V., Manfroid, I., Peers, B., Voz, M.L. (2022) Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. PLoS Genetics. 18:e1010109
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
1 - 10 of 52
Show