Gene
gh1
- ID
- ZDB-GENE-030725-2
- Name
- growth hormone 1
- Symbol
- gh1 Nomenclature History
- Previous Names
-
- gh (1)
- ghl
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables growth hormone activity and growth hormone receptor binding activity. Acts upstream of or within adipose tissue development and positive regulation of lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adenohypophyseal placode; bone tissue; hematopoietic multipotent progenitor cell; hypophysis; and male organism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including CSH1 (chorionic somatomammotropin hormone 1); CSH2 (chorionic somatomammotropin hormone 2); and GH1 (growth hormone 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 93 figures from 59 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-gh1 | Hu et al., 2019 | |
CRISPR2-gh1 | Hu et al., 2019 | |
MO1-gh1 | N/A | Zhu et al., 2007 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
isolated growth hormone deficiency type IA | Alliance | Growth hormone deficiency, isolated, type IA | 262400 |
isolated growth hormone deficiency type IB | Alliance | Growth hormone deficiency, isolated, type IB | 612781 |
isolated growth hormone deficiency type II | Alliance | Growth hormone deficiency, isolated, type II | 173100 |
Kowarski syndrome | 262650 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Four-helical cytokine-like, core | Somatotropin | Somatotropin hormone, conserved site | Somatotropin/prolactin |
---|---|---|---|---|---|---|
UniProtKB:Q1JQ34 | InterPro | 210 |
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Interactions and Pathways
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-2.2actb1:gh1,-2.2actb1:GFP) |
|
| 1 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-248K5 | ||
Encodes | cDNA | MGC:136327 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001020492 (1) | 1210 nt | ||
Genomic | GenBank:BX005440 (1) | 115165 nt | ||
Polypeptide | UniProtKB:Q1JQ34 (1) | 210 aa |
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Guan, K., Ye, M., Guo, A., Chen, X., Shan, Y., Li, X. (2024) Deficiency of leap2 promotes somatic growth in zebrafish: Involvement of the growth hormone system. Heliyon. 10:e36397e36397
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Roisman-Geller, N., Pisanty, O., Weinberger, A., Gajbhiye, D.S., Golan, M., Gothilf, Y. (2024) Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish. International Journal of Molecular Sciences. 25(13):
- Ventura Fernandes, B.H., Junqueira, M.S., MacRae, C., Silveira de Carvalho, L.R. (2024) Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors. Frontiers in endocrinology. 15:14666381466638
- Awasthi, N., Ward, A.C., Liongue, C. (2023) Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth. Frontiers in bioscience (Landmark edition). 28:187187
- Dai, X., Pradhan, A., Liu, J., Liu, R., Zhai, G., Zhou, L., Dai, J., Shao, F., Yuan, Z., Wang, Z., Yin, Z. (2023) Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions. Biology of sex differences. 14:5353
- Guan, K., Shan, C., Guo, A., Gao, X., Li, X. (2023) Ghrelin regulates hyperactivity-like behaviors via growth hormone signaling pathway in zebrafish (Danio rerio). Frontiers in endocrinology. 14:11632631163263
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