Gene
tgfb2
- ID
- ZDB-GENE-030723-3
- Name
- transforming growth factor, beta 2
- Symbol
- tgfb2 Nomenclature History
- Previous Names
-
- tgf beta 2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within roof of mouth development and sclerotome development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including head; mesoderm; optic cup; otic placode; and pericardial region. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4; colorectal cancer; and pancreatic adenosquamous carcinoma. Orthologous to human TGFB2 (transforming growth factor beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tgfb2 | (2) | |
| CRISPR2-tgfb2 | (2) | |
| MO1-tgfb2 | N/A | Swartz et al., 2011 |
| MO2-tgfb2 | N/A | (2) |
| MO3-tgfb2 | N/A | Monteiro et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Loeys-Dietz syndrome 4 | Alliance | Loeys-Dietz syndrome 4 | 614816 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR003940 | Transforming growth factor beta-2 proprotein |
| Family | IPR015615 | Transforming growth factor-beta-related |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor-beta | Transforming growth factor beta-2 proprotein | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SZV4 | InterPro | 411 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-65B3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-288I20 | ZFIN Curated Data | |
| Encodes | EST | tgf_beta_2 | Chen et al., 2003 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194385 (1) | 1242 nt | ||
| Genomic | GenBank:CU207260 (1) | 172886 nt | ||
| Polypeptide | UniProtKB:Q7SZV4 (1) | 411 aa |
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Zhang, J., Li, P., Sun, L., Jiang, N., Guo, W., Wang, J., Gao, F., Li, J., Li, H., Zhang, J., Mu, H., Hu, Y., Cui, X. (2023) Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22927e22927
- Rayrikar, A.Y., Wagh, G.A., Santra, M., Patra, C. (2022) Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development (Cambridge, England). 150(1):
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Deng, Y., Ma, J., Weng, X., Wang, Y., Li, M., Yang, T., Dou, Z., Yin, Z., Shang, J. (2021) Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. Life (Basel, Switzerland). 11(5):
- Ibrahim, S., Johnson, M., Stephens, C.H., Xu, J., Moore, R., Mariani, A., Contreras, C., Syed, F., Mirmira, R.G., Anderson, R.M., Sims, E.K. (2021) β-Cell pre-miR-21 Induces Dysfunction and Loss of Cellular Identity by Targeting Transforming Growth Factor Beta 2 (Tgfb2) and Smad Family Member 2 (Smad2) mRNAs. Molecular metabolism. 53:101289
- Molina-Villa, T., Ramírez-Vidal, L., Mendoza, V., Escalante-Alcalde, D., López-Casillas, F. (2021) Chordacentrum mineralization is delayed in zebrafish betaglycan-null mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(1):213-225
- Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:632372
- Conedera, F.M., Quintela Pousa, A.M., Presby, D.M., Mercader, N., Enzmann, V., Tschopp, M. (2020) Diverse Signaling by TGFβ Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis. Cellular and molecular neurobiology. 41(1):43-62
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