Gene
mxb
- ID
- ZDB-GENE-030721-6
- Name
- myxovirus (influenza) resistance B
- Symbol
- mxb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within response to virus. Predicted to be active in several cellular components, including microtubule; nucleus; and synapse. Is expressed in head kidney. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to several human genes including MX2 (MX dynamin like GTPase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mxb | Sun et al., 2019 | |
| CRISPR2-mxb | Sun et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamin | Dynamin, GTPase domain | Dynamin GTPase effector | Dynamin, GTPase region, conserved site | Dynamin, N-terminal | Dynamin stalk domain | Dynamin-type guanine nucleotide-binding (G) domain | GTPase effector domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JKI4 | InterPro | 627 | |||||||||
| UniProtKB:B3DH90 | InterPro | 550 | |||||||||
| UniProtKB:Q800G8 | InterPro | 627 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-197A6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194096 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194116 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128672 (1) | 1819 nt | ||
| Genomic | GenBank:CT998565 (1) | 169303 nt | ||
| Polypeptide | UniProtKB:B8JKI4 (1) | 627 aa |
No data available
- Wang, Z., Chen, X., Zhu, C., Fan, S., Tang, J., Deng, H., Sun, X., Liu, X., Xiao, W. (2025) Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 122:e2320644122e2320644122
- Pessoa Rodrigues, C., Collins, J.M., Yang, S., Martinez, C., Kim, J.W., Lama, C., Nam, A.S., Alt, C., Lin, C., Zon, L.I. (2024) Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science (New York, N.Y.). 385:eadn1629eadn1629
- Qu, Z.L., Gong, X.Y., An, L.L., Sun, H.Y., Guo, W.H., Luan, H.Y., Wu, M.Y., Dan, C., Gui, J.F., Zhang, Y.B. (2024) Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience. 27:109497109497
- Wang, Z., Zhu, C., Sun, X., Deng, H., Liu, W., Jia, S., Bai, Y., Xiao, W., Liu, X. (2024) Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α. Journal of virology. :e0149124e0149124
- Chen, L., Zhong, S., Wang, Y., Wang, X., Liu, Z., Hu, G. (2023) Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. International Journal of Molecular Sciences. 24(19):
- Xiong, S.T., Ying, Y.R., Long, Z., Li, J.H., Zhang, Y.B., Xiao, T.Y., Zhao, X. (2023) Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. International journal of biological macromolecules. 240:124384
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- An, L.L., Zhao, X., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., Guo, W.H., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response. Frontiers in immunology. 13:861262
- Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821
- Jiang, J., Gu, J., Zhan, A., Mao, M., Liu, Y., Wang, H., Mao, Y. (2022) Cloning, Exogenous Expression and Function Analysis of Interferon-γ from Gadus macrocephalus. Viruses. 14(10):
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