Gene
pcdh10b
- ID
- ZDB-GENE-030721-4
- Name
- protocadherin 10b
- Symbol
- pcdh10b Nomenclature History
- Previous Names
-
- wu:fq16b02
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within paraxial mesoderm development; somitogenesis; and thalamus development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior axial hypoblast; mesoderm; nervous system; spinal cord neural tube; and trunk. Orthologous to human PCDH10 (protocadherin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu710 (28 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| co1009 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la019044Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027561Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nv1308 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa1760 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22534 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42436 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42437 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pcdh10b | Williams et al., 2018 | |
| CRISPR2-pcdh10b | Tsai et al., 2020 | |
| CRISPR3-pcdh10b | Tsai et al., 2020 | |
| CRISPR4-pcdh10b | Tsai et al., 2020 | |
| CRISPR5-pcdh10b | Tsai et al., 2020 | |
| MO1-pcdh10b | N/A | (2) |
| MO2-pcdh10b | N/A | Williams et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin, cytoplasmic C-terminal domain | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin/Cadherin-related Cell Adhesion |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q805F0 | InterPro | 1026 | ||||||
| UniProtKB:A0A8M3B0C3 | InterPro | 974 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh10b-201
(1)
|
Ensembl | 4,672 nt | ||
| mRNA |
pcdh10b-202
(1)
|
Ensembl | 447 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-148J13 | ||
| Contained in | BAC | DKEY-216J10 | ZFIN Curated Data | |
| Encodes | EST | eu710 | Thisse et al., 2005 | |
| Encodes | EST | fq16b02 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:85860 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182885 (1) | 4743 nt | ||
| Genomic | GenBank:CR954249 (1) | 221587 nt | ||
| Polypeptide | UniProtKB:Q805F0 (1) | 1026 aa |
No data available
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
- Kindt, L.M., Coughlin, A.R., Perosino, T.R., Ersfeld, H., Hampton, M., Liang, J.O. (2018) Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing. Genesis (New York, N.Y. : 2000). 56(3):e23096
- Tsai, T.C., Shih, C.C., Chien, H.P., Yang, A.H., Lu, J.K., Lu, J.H. (2018) Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos. BMC Developmental Biology. 18:5
- Williams, J.S., Hsu, J.Y., Rossi, C.C., Artinger, K.B. (2018) Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Developmental Biology. 444 Suppl 1:S274-S286
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Payumo, A.Y., McQuade, L.E., Walker, W.J., Yamazoe, S., Chen, J.K. (2016) Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nature Chemical Biology. 12(9):694-701
- Cooper, S.R., Emond, M.R., Duy, P.Q., Liebau, B.G., Wolman, M.A., Jontes, J.D. (2015) Protocadherins control the modular assembly of neuronal columns in the zebrafish optic tectum. The Journal of cell biology. 211:807-14
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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