Gene
ifnphi1
- ID
- ZDB-GENE-030721-3
- Name
- interferon phi 1
- Symbol
- ifnphi1 Nomenclature History
- Previous Names
-
- ifn1
- ifn
- ifnab (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and cytokine receptor binding activity. Acts upstream of or within several processes, including defense response to virus; regulation of defense response to virus by host; and response to exogenous dsRNA. Predicted to be located in extracellular space. Is expressed in brain; gill; immune system; integument; and liver.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 90 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu784 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu7894 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ip9 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la023992Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ifnphi1 | (2) | |
| MO1-ifnphi1 | N/A | Levraud et al., 2007 |
| MO2-ifnphi1 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interferon alpha/beta/delta |
|---|---|---|---|---|
| UniProtKB:Q8AY12 | InterPro PDB | 185 | ||
| UniProtKB:Q800H1 | InterPro | 179 | ||
| UniProtKB:A0A8M1PF76 | InterPro | 181 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ifnphi1-201
(1)
|
Ensembl | 736 nt | ||
| mRNA |
ifnphi1-202
(1)
|
Ensembl | 612 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ifnphi1:mCherry) |
|
| 2 | (6) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-104G4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-248K5 | ZFIN Curated Data | |
| Encodes | EST | eu784 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193611 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207640 (1) | 1078 nt | ||
| Genomic | GenBank:BX005440 (2) | 115165 nt | ||
| Polypeptide | UniProtKB:Q8AY12 (1) | 185 aa |
No data available
- Huang, J., Li, L., Xu, L., Feng, L., Wang, Y., Sik, A.G., Jin, M., Wang, R., Liu, K., Li, X. (2025) Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways. Marine drugs. 23:
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Wang, Z., Chen, X., Zhu, C., Fan, S., Tang, J., Deng, H., Sun, X., Liu, X., Xiao, W. (2025) Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 122:e2320644122e2320644122
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Chen, K., Tian, J., Shi, Y., Xie, T., Huang, W., Jia, Z., Zhang, Y., Yuan, G., Yan, H., Wang, J., Zou, J. (2024) Distinct antiviral activities of IFNφ1 and IFNφ4 in zebrafish. Fish & shellfish immunology. 146:109396
- Ding, Y., Tong, J., Luo, G., Sun, R., Bei, C., Feng, Z., Meng, L., Wang, F., Zhou, J., Chen, Z., Li, D., Fan, Y., Song, S., Wang, D., Feng, C.G., Liu, H., Chen, Q., Yan, B., Gao, Q. (2024) Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway. iScience. 27:109807109807
- Li, Z., Li, J., Li, Z., Song, Y., Wang, Y., Wang, C., Yuan, L., Xiao, W., Wang, J. (2024) Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3. PLoS pathogens. 20:e1012227e1012227
- Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
- Martínez-López, N., Pereiro, P., Saco, A., Lama, R., Figueras, A., Novoa, B. (2024) Characterization of a fish-specific Immunoglobulin-like domain-containing protein (Igldcp) in zebrafish (Danio rerio) induced after nodavirus infection. Developmental and comparative immunology. 162:105285
- Pessoa Rodrigues, C., Collins, J.M., Yang, S., Martinez, C., Kim, J.W., Lama, C., Nam, A.S., Alt, C., Lin, C., Zon, L.I. (2024) Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science (New York, N.Y.). 385:eadn1629eadn1629
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