Gene
plp1b
- ID
- ZDB-GENE-030710-6
- Name
- proteolipid protein 1b
- Symbol
- plp1b Nomenclature History
- Previous Names
-
- dm20 (1)
- DMalpha2a
- DMalpha2b
- DMalpha2c
- fv76c02
- wu:fv76c02
- zgc:91786
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of myelin sheath. Predicted to be involved in axon development and central nervous system myelination. Predicted to be located in membrane. Predicted to be active in myelin sheath and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu446 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 2 | Alliance | Spastic paraplegia 2, X-linked | 312920 |
| Pelizaeus-Merzbacher disease | Alliance | Pelizaeus-Merzbacher disease | 312080 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001614 | Myelin proteolipid protein PLP |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Myelin proteolipid protein PLP |
|---|---|---|---|
| UniProtKB:A0A8M2BCB3 | InterPro | 280 | |
| UniProtKB:Q8UUT2 | InterPro | 257 | |
| UniProtKB:Q8UUT5 | InterPro | 245 | |
| UniProtKB:Q8UUT3 | InterPro | 279 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-125I10 | ZFIN Curated Data | |
| Encodes | EST | eu446 | Thisse et al., 2005 | |
| Encodes | EST | fj36d03 | ZFIN Curated Data | |
| Encodes | EST | fv76c02 | ||
| Encodes | cDNA | MGC:91786 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005586 (1) | 1811 nt | ||
| Genomic | GenBank:BX640521 (1) | 126380 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCB3 (1) | 280 aa |
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Berdowski, W.M., van der Linde, H.C., Breur, M., Oosterhof, N., Beerepoot, S., Sanderson, L., Wijnands, L.I., de Jong, P., Tsai-Meu-Chong, E., de Valk, W., de Witte, M., van IJcken, W.F.J., Demmers, J., van der Knaap, M.S., Bugiani, M., Wolf, N.I., van Ham, T.J. (2022) Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy. Acta Neuropathologica. 144(2):211-239
- Deng, J., Wang, Y., Hu, M., Lin, J., Li, Q., Liu, C., Xu, X. (2022) Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism. Frontiers in molecular neuroscience. 15:904935
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Spencer, S.A., Suárez-Pozos, E., Verdugo, J.S., Wang, H., Afshari, F.S., Guo, L., Manam, S., Yasuda, D., Ortega, A., Lister, J.A., Ishii, S., Zhang, Y., Fuss, B. (2022) Lysophosphatidic acid signaling via LPA6 : a negative modulator of developmental oligodendrocyte maturation. Journal of neurochemistry. 163(6):478-499
- Farías-Serratos, B.M., Lazcano, I., Villalobos, P., Darras, V.M., Orozco, A. (2021) Thyroid hormone deficiency during zebrafish development impairs central nervous system myelination. PLoS One. 16:e0256207
- Turan, F., Yilmaz, Ö., Schünemann, L., Lindenberg, T.T., Kalanithy, J.C., Harder, A., Ahmadi, S., Duman, T., MacDonald, R.B., Winter, D., Liu, C., Odermatt, B. (2021) Effect of modulating glutamate signaling on myelinating oligodendrocytes and their development-A study in the zebrafish model. Journal of neuroscience research. 99(11):2774-2792
- Wiweger, M., Majewski, L., Adamek-Urbanska, D., Wasilewska, I., Kuznicki, J. (2021) npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Frontiers in Cellular Neuroscience. 15:647860
- Ling, Y., Sun, L., Wang, D., Jiang, J., Sun, W., Ai, W., Wang, X., Wang, H. (2020) Triclosan induces zebrafish neurotoxicity by abnormal expression of miR-219 targeting oligodendrocyte differentiation of central nervous system. Archives of toxicology. 94(3):857-871
- Sarti, S., De Paolo, R., Ippolito, C., Pucci, A., Pitto, L., Poliseno, L. (2020) Inducible modulation of miR-204 levels in a zebrafish melanoma model. Biology Open. 9(11):
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