Gene
anxa11b
- ID
- ZDB-GENE-030707-5
- Name
- annexin A11b
- Symbol
- anxa11b Nomenclature History
- Previous Names
-
- cb755 (1)
- hm:zeh0376
- zeh0376
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cytokinetic process and phagocytosis. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in several structures, including cardiovascular system; digestive system; immature eye; integument; and sensory system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23 and inclusion body myopathy and brain white matter abnormalities. Orthologous to human ANXA11 (annexin A11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb755 (46 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018326Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22183 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 23 | Alliance | Amyotrophic lateral sclerosis 23 | 617839 |
| inclusion body myopathy and brain white matter abnormalities | Alliance | Inclusion body myopathy and brain white matter abnormalities | 619733 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Annexin | Annexin repeat | Annexin repeat, conserved site | Annexin superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q804G3 | InterPro | 485 | ||||
| UniProtKB:A0A8M1PC84 | InterPro | 485 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anxa11b-201
(1)
|
Ensembl | 2,835 nt | ||
| ncRNA |
anxa11b-002
(1)
|
Ensembl | 771 nt | ||
| ncRNA |
anxa11b-003
(1)
|
Ensembl | 117 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-74H19 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-2177F3 | ZFIN Curated Data | |
| Encodes | EST | cb755 | Thisse et al., 2001 | |
| Encodes | EST | zeh0376 | ||
| Encodes | cDNA | MGC:85708 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181766 (1) | 2659 nt | ||
| Genomic | GenBank:CU611055 (2) | 32051 nt | ||
| Polypeptide | UniProtKB:A0A8M1PC84 (1) | 485 aa |
- Marchica, V., Biasetti, L., Barnard, J., Li, S., Nikolaou, N., Frosch, M.P., Lucente, D.E., Eldaief, M., King, A., Fanto, M., Troakes, C., Houart, C., Smith, B.N. (2024) Annexin A11 mutations are associated with nuclear envelope dysfunction in vivo and in human tissue. Brain : a journal of neurology. 148(1):276-290
- Rostad, K.O., Trognitz, T., Frøyset, A.K., Bifulco, E., Fladmark, K.E. (2024) Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout Zebrafish. Antioxidants (Basel, Switzerland). 13(12):
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Saxena, S., Purushothaman, S., Meghah, V., Bhatti, B., Poruri, A., Meena Lakshmi, M.G., Sarath Babu, N., Murthy, C.L., Mandal, K.K., Kumar, A., Idris, M.M. (2016) Role of Annexin gene and its regulation during zebrafish caudal fin regeneration. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(3):551-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Roostalu, U., and Strähle, U. (2012) In Vivo imaging of molecular interactions at damaged sarcolemma. Developmental Cell. 22(3):515-529
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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