Gene
plk4
- ID
- ZDB-GENE-030619-14
- Name
- polo-like kinase 4 (Drosophila)
- Symbol
- plk4 Nomenclature History
- Previous Names
-
- stk18 (1)
- wu:fi33g07
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within centriole assembly; cilium assembly; and developmental growth. Predicted to be located in deuterosome; microtubule organizing center; and nucleolus. Predicted to be active in nucleus. Is expressed in brain; eye; nervous system; and pronephros. Used to study ciliopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Martin et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-plk4 | N/A | Eckfeldt et al., 2005 |
| MO2-plk4 | N/A | Martin et al., 2014 |
| MO3-plk4 | N/A | Martin et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| microcephaly and chorioretinopathy 2 | Alliance | Microcephaly and chorioretinopathy, autosomal recessive, 2 | 616171 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | AB/TU + MO2-plk4 + MO3-plk4 | standard conditions | Martin et al., 2014 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Plk4, C-terminal polo-box domain | Plk4, first cryptic polo-box domain | Plk4-like, second cryptic polo-box domain superfamily | Plk4, second cryptic polo-box domain | POLO box domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, first cryptic polo-box domain superfamily | Tyrosine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B5U8 | InterPro | 963 | ||||||||||
| UniProtKB:Q7ZVS3 | InterPro | 940 | ||||||||||
| UniProtKB:F1RB74 | InterPro | 941 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(2A-LOXP-mCherry-LOXP-plk4) |
| 1 | Buglak et al., 2020 | ||
| Tg(5xUAS:plk4) |
|
| 1 | Buglak et al., 2020 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001118892 (1) | 3299 nt | ||
| Genomic | GenBank:CR405694 (1) | 207188 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5U8 (1) | 963 aa |
- Buglak, D.B., Kushner, E.J., Marvin, A.P., Davis, K.L., Bautch, V.L. (2020) Excess centrosomes disrupt vascular lumenization and endothelial cell adherens junctions. Angiogenesis. 23(4):567-575
- Sredni, S.T., Suzuki, M., Yang, J.P., Topczewski, J., Bailey, A.W., Gokirmak, T., Gross, J.N., de Andrade, A., Kondo, A., Piper, D.R., Tomita, T. (2017) A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. Pediatric blood & cancer. 64(11)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Rapchak, C.E., Patel, N., Hudson, J., Crawford, M. (2015) Developmental role of plk4 in Xenopus laevis and Danio rerio: implications for Seckel Syndrome. Biochemistry and cell biology = Biochimie et biologie cellulaire. 93(4):396-404
- Zhou, F., Narasimhan, V., Shboul, M., Chong, Y.L., Reversade, B., Roy, S. (2015) Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Current biology : CB. 25(24):3267-73
- Fontenille, L., Rouquier, S., Lutfalla, G., Giorgi, D. (2014) Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development. Cell cycle (Georgetown, Tex.). 13(7):1101-14
- Martin, C.A., Ahmad, I., Klingseisen, A., Hussain, M.S., Bicknell, L.S., Leitch, A., Nürnberg, G., Toliat, M.R., Murray, J.E., Hunt, D., Khan, F., Ali, Z., Tinschert, S., Ding, J., Keith, C., Harley, M.E., Heyn, P., Müller, R., Hoffmann, I., Daire, V.C., Dollfus, H., Dupuis, L., Bashamboo, A., McElreavey, K., Kariminejad, A., Mendoza-Londono, R., Moore, A.T., Saggar, A., Schlechter, C., Weleber, R., Thiele, H., Altmüller, J., Höhne, W., Hurles, M.E., Noegel, A.A., Baig, S.M., Nürnberg, P., Jackson, A.P. (2014) Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nature Genetics. 46:1283-92
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Wang, L., Fu, C., Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A., Jing, Q., Liu, T., and Zhou, Y. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development (Cambridge, England). 140(13):2755-2764
- Zhong, H., Xin, S., Zhao, Y., Lu, J., Li, S., Gong, J., Yang, Z., and Lin, S. (2010) Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Molecular Biosystems. 6(8):1463-1468
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