Gene
ube2a
- ID
- ZDB-GENE-030616-72
- Name
- ubiquitin-conjugating enzyme E2A (RAD6 homolog)
- Symbol
- ube2a Nomenclature History
- Previous Names
-
- mp:zf637-2-000771
- si:bz46j2.4
- wu:fa01h11
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be part of HULC complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to human UBE2A (ubiquitin conjugating enzyme E2 A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64109 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ube2a | N/A | (2) |
| MO2-ube2a | N/A | Huang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked intellectual disability Nascimento type | Alliance | Intellectual developmental disorder, X-linked syndromic, Nascimento type | 300860 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ubiquitin-conjugating enzyme | Ubiquitin-conjugating enzyme, active site | Ubiquitin-conjugating enzyme E2, catalytic core domain | Ubiquitin-conjugating enzyme/RWD-like |
|---|---|---|---|---|---|---|
| UniProtKB:Q789K9 | InterPro | 152 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-231B5 | ZFIN Curated Data | |
| Contained in | BAC | RP71-46J2 | ZFIN Curated Data | |
| Encodes | EST | fa01h11 | ZFIN Curated Data | |
| Encodes | EST | zf637-2-000771 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64109 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201273 (1) | 1626 nt | ||
| Genomic | GenBank:BX247946 (1) | 156559 nt | ||
| Polypeptide | UniProtKB:Q789K9 (1) | 152 aa |
- Antón-Galindo, E., Adel, M.R., García-González, J., Leggieri, A., López-Blanch, L., Irimia, M., Norton, W.H.J., Brennan, C.H., Fernàndez-Castillo, N., Cormand, B. (2024) Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Translational psychiatry. 14:9999
- Castellini, M.E., Spagnolli, G., Poggi, L., Biasini, E., Casarosa, S., Messina, A. (2023) Identification of the zebrafish homologues of IMPG2, a retinal proteoglycan. Cell and tissue research. 394(1):93-105
- Huttner, I.G., Santiago, C.F., Jacoby, A., Cheng, D., Trivedi, G., Cull, S., Cvetkovska, J., Chand, R., Berger, J., Currie, P.D., Smith, K.A., Fatkin, D. (2023) Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish. Journal of cardiovascular development and disease. 10(10):
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Covello, G., Rossello, F.J., Filosi, M., Gajardo, F., Duchemin, A.L., Tremonti, B.F., Eichenlaub, M., Polo, J.M., Powell, D., Ngai, J., Allende, M.L., Domenici, E., Ramialison, M., Poggi, L. (2020) Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases. FASEB bioAdvances. 2:434-448
- Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O. (2020) The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model. Genes. 11(4):
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Völkel, P., Bary, A., Raby, L., Chapart, A., Dupret, B., Le Bourhis, X., Angrand, P.O. (2019) Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development. Scientific Reports. 9:4319
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