Gene
ppp1r14bb
- ID
- ZDB-GENE-030616-595
- Name
- protein phosphatase 1, regulatory (inhibitor) subunit 14Bb
- Symbol
- ppp1r14bb Nomenclature History
- Previous Names
-
- PLCB3N (1)
- ppp1r14b
- si:zc188c22.2
- si:zc194c5.1
- wu:fa01d09
- wu:fb59a08
- wu:fc32d08
- wu:fk27d06
- zgc:91822
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in innate immune response. Is expressed in head mesenchyme; intermediate cell mass of mesoderm; pectoral fin musculature; solid lens vesicle; and somite. Orthologous to human PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91822 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct50aGt | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ppp1r14bb | Jurgens et al., 2025 | |
| CRISPR2-ppp1r14bb | Jurgens et al., 2025 | |
| CRISPR3-ppp1r14bb | Jurgens et al., 2025 | |
| CRISPR4-ppp1r14bb | Jurgens et al., 2025 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CPI-17 | CPI-17 superfamily |
|---|---|---|---|---|
| UniProtKB:Q7ZZ37 | InterPro | 128 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp1r14bb-201
(1)
|
Ensembl | 2,621 nt | ||
| mRNA |
ppp1r14bb-202
(1)
|
Ensembl | 2,782 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-188C22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-194C5 | ||
| Contains | SNP | rs3728114 | ZFIN Curated Data | |
| Encodes | EST | fa01d09 | ||
| Encodes | EST | fb59a08 | ||
| Encodes | EST | fc32d08 | ||
| Encodes | EST | fk27d06 | ||
| Encodes | cDNA | MGC:91822 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192988 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002692 (1) | 2650 nt | ||
| Genomic | GenBank:AL772193 (1) | 192531 nt | ||
| Polypeptide | UniProtKB:Q7ZZ37 (1) | 128 aa |
- Jurgens, J.A., Matos Ruiz, P.M., King, J., Foster, E.E., Berube, L., Chan, W.M., Barry, B.J., Jeong, R., Rothman, E., Whitman, M.C., MacKinnon, S., Rivera-Quiles, C., Pratt, B.M., Easterbrooks, T., Mensching, F.M., Di Gioia, S.A., Pais, L., England, E.M., de Berardinis, T., Magli, A., Koc, F., Asakawa, K., Kawakami, K., O'Donnell-Luria, A., Hunter, D.G., Robson, C.D., Bulyk, M.L., Engle, E.C. (2025) Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays. Investigative ophthalmology & visual science. 66:6262
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Marisca, R., Hoche, T., Agirre, E., Hoodless, L.J., Barkey, W., Auer, F., Castelo-Branco, G., Czopka, T. (2020) Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience. 23(3):363-374
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Trinh, A., Hochgreb, T., Graham, M., Wu, D., Ruf-Zamojski, F., Jayasena, C.S., Saxena, A., Hawk, R., Gonzalez-Serricchio, A., Dixson, A., Chow, E., Gonzales, C., Leung, H.Y., Solomon, I., Bronner-Fraser, M., Megason, S.G., and Fraser, S.E. (2011) A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes & Development. 25(21):2306-20
- Weiser, D.C., Row, R.H., and Kimelman, D. (2009) Rho-regulated Myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development (Cambridge, England). 136(14):2375-2384
- Hoffmann, J.L., Thomason, R.G., Lee, D.M., Brill, J.L., Price, B.B., Carr, G.J., and Versteeg, D.J. (2008) Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Aquatic toxicology (Amsterdam, Netherlands). 87(2):69-80
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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