Gene

slc1a4

ID

ZDB-GENE-030616-566

Name

solute carrier family 1 member 4

Symbol

slc1a4 Nomenclature History

Previous Names

si:zc101n13.5
zgc:92817

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable L-amino acid transmembrane transporter activity. Acts upstream of or within regulation of axon regeneration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; pancreatic system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to human SLC1A4 (solute carrier family 1 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92817 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Li et al., 2024
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc1a4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spastic tetraplegia, thin corpus callosum, and progressive microcephaly	Alliance	Spastic tetraplegia, thin corpus callosum, and progressive microcephaly	616657

Associated With slc1a4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018107	Sodium:dicarboxylate symporter, conserved site
Family	IPR001991	Sodium:dicarboxylate symporter
Family	IPR050746	Dicarboxylate/Amino Acid:Cation Symporter
Homologous_superfamily	IPR036458	Sodium:dicarboxylate symporter superfamily