Gene
abcc4
- ID
- ZDB-GENE-030616-511
- Name
- ATP binding cassette subfamily C member 4 (PEL blood group)
- Symbol
- abcc4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables ABC-type transporter activity and efflux transmembrane transporter activity. Acts upstream of or within detoxification of inorganic compound and regulation of cilium assembly. Located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1019 (12 images)
- eu668 (1 image)
- eu872 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| gyf29 | Allele with one insertion | Exon 4 | Unknown | CRISPR | |
| ihb366 | Allele with one deletion | Exon 7 | Unknown | CRISPR | |
| ihb866 | Allele with one deletion | Exon 7 | Unknown | CRISPR | |
| ihb867 | Allele with one insertion | Exon 7 | Unknown | CRISPR | |
| sa16292 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20625 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38538 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf560 | Allele with one point mutation | Exon 17 | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-abcc4 | (3) | |
| CRISPR2-abcc4 | Xue et al., 2023 | |
| CRISPR3-abcc4 | Zebrafish Nomenclature Committee | |
| MO1-abcc4 | N/A | Jin et al., 2014 |
| MO2-abcc4 | N/A | Lu et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Domain | IPR030240 | ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 1 | ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 2 | ATP-binding cassette transporter C-like | Cystic fibrosis transmembrane conductance regulator | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8QFL6 | InterPro | 1327 | ||||||||||
| UniProtKB:A0A8M1N2Y9 | InterPro | 1331 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(Cca.Actb:abcc4-FLAG) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-181L5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-241A17 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-52I16 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-202L16 | ||
| Contained in | PAC | BUSM1-228E24 | ZFIN Curated Data | |
| Encodes | EST | cb1019 | Thisse et al., 2001 | |
| Encodes | EST | eu668 | Thisse et al., 2005 | |
| Encodes | EST | eu872 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007038 (1) | 5790 nt | ||
| Genomic | GenBank:BX649550 (1) | 170472 nt | ||
| Polypeptide | UniProtKB:A0A8M1N2Y9 (1) | 1331 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Xue, N., Liu, X., Zhang, D., Wu, Y., Zhong, Y., Wang, J., Fan, W., Jiang, H., Zhu, B., Ge, X., Gonzalez, R.V.L., Chen, L., Zhang, S., She, P., Zhong, Z., Sun, J., Chen, X., Wang, L., Gu, Z., Zhu, P., Liu, M., Li, D., Zhong, T.P., Zhang, X. (2023) Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD. Nature communications. 14:12241224
- Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- Lu, X., Long, Y., Li, X., Zhang, L., Li, Q., Wen, H., Zhong, S., Cui, Z. (2021) Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead. International Journal of Molecular Sciences. 22(4):
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Moraes, J.S., da Silva Nornberg, B.F., Castro, M.R., Vaz, B.D.S., Mizuschima, C.W., Marins, L.F.F., Martins, C.M.G. (2020) Zebrafish (Danio rerio) ability to activate ABCC transporters after exposure to glyphosate and its formulation Roundup Transorb®. Chemosphere. 248:125959
- Wu, L., Chen, H., Ru, H., Li, Y., Yao, F., Ni, Z., Zhong, L. (2020) Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio). Toxicology letters. 331:143-151
- Fernanda Moreira, L., Juliana Zomer, S., Marta Marques, S. (2019) Modulation of the multixenobiotic resistance mechanism in Danio rerio hepatocyte culture (ZF-L) after exposure to glyphosate and Roundup®. Chemosphere. 228:159-165
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