Gene
tap2a
- ID
- ZDB-GENE-030616-245
- Name
- transporter associated with antigen processing, subunit type a
- Symbol
- tap2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable ABC-type peptide transporter activity. Acts upstream of or within response to cadmium ion. Predicted to be located in endoplasmic reticulum membrane and mitochondrial inner membrane. Predicted to be part of MHC class I peptide loading complex. Predicted to be active in membrane. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in several diseases, including aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); dengue hemorrhagic fever; and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Gonzalez et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR039421 | Type 1 protein exporter |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q801W2 | InterPro | 725 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | abcb3l1-001 (1) | Havana | 2,178 nt | ||
| mRNA |
tap2a-201
(1)
|
Ensembl | 3,190 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-386O6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-51F10 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-262K18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194955 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194970 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006594 (1) | 2178 nt | ||
| Genomic | GenBank:BX510994 (1) | 186973 nt | ||
| Polypeptide | UniProtKB:Q801W2 (1) | 725 aa |
No data available
- Grimholt, U. (2018) Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. BMC Evolutionary Biology. 18:25
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Zhang, L., Jin, Y., Han, Z., Liu, H., Shi, L., Hua, X., A Doering, J., Tang, S., P Giesy, J., Yu, H. (2017) INTEGRATED IN SILICO AND IN VIVO APPROACHES TO INVESTIGATE EFFECTS OF BDE-99 MEDIATED BY THE NUCLEAR RECEPTORS ON DEVELOPING ZEBRAFISH. Environmental toxicology and chemistry. 37(3):780-787
- Lerebours, A., To, V.V., Bourdineaud, J.P. (2016) Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination. Journal of applied toxicology : JAT. 36:1551-1557
- McConnell, S.C., Hernandez, K.M., Wcisel, D.J., Kettleborough, R.N., Stemple, D.L., Yoder, J.A., Andrade, J., de Jong, J.L. (2016) Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America. 113(34):E5014-23
- Yoon, S., Alnabulsi, A., Wang, T.Y., Lee, P.T., Chen, T.Y., Bird, S., Zou, J., Secombes, C.J. (2016) Analysis of interferon gamma protein expression in zebrafish (Danio rerio). Fish & shellfish immunology. 57:79-86
- Gentès, S., Maury-Brachet, R., Feng, C., Pedrero, Z., Tessier, E., Legeay, A., Mesmer-Dudons, N., Baudrimont, M., Maurice, L., Amouroux, D., Gonzalez, P. (2015) Specific effects of dietary methylmercury and inorganic mercury in zebrafish (Danio rerio) determined by genetic, histological and metallothionein responses. Environmental science & technology. 49(24):14560-9
- Liu, H., Tang, S., Zheng, X., Zhu, Y., Ma, Z., Liu, C., Hecker, M., Saunders, D.M., Giesy, J.P., Zhang, X., Yu, H. (2015) Bioaccumulation, biotransformation and toxicity of BDE-47, 6-OH-BDE-47 and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio). Environmental science & technology. 49(3):1823-33
- Ma, Z., Yu, Y., Tang, S., Liu, H., Su, G., Xie, Y., Giesy, J.P., Hecker, M., Yu, H. (2015) Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 169:196-203
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
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