Gene
stat1b
- ID
- ZDB-GENE-030616-23
- Name
- signal transducer and activator of transcription 1b
- Symbol
- stat1b Nomenclature History
- Previous Names
-
- si:by134g18.3
- si:by51f19.2
- si:dz199m19.2
- si:dz73o4.3
- si:dz87i4.1
- si:xx-51f19.2
- wu:fi49f02
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleoplasm. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cardiovascular system; eye; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
- Genome Resources
- Note
-
novel protein similar to human signal transduction and activator of transcription 1 (STAT1)
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Song et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| lv51 | Allele with one insertion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stat1b | (2) | |
| CRISPR2-stat1b | Zhou et al., 2018 | |
| MO1-stat1b | N/A | (2) |
| MO2-stat1b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic mucocutaneous candidiasis | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
| immunodeficiency 31A | Alliance | Immunodeficiency 31A, mycobacteriosis, autosomal dominant | 614892 |
| immunodeficiency 31B | Alliance | Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive | 613796 |
| immunodeficiency 31C | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B5U5 | InterPro | 708 | |||||||||||
| UniProtKB:A0A8M9QF99 | InterPro | 634 | |||||||||||
| UniProtKB:A0A8M9PRY3 | InterPro | 609 | |||||||||||
| UniProtKB:A0A8M9Q4I2 | InterPro | 438 | |||||||||||
| UniProtKB:A0A8M9QAL7 | InterPro | 683 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000001761 (1) | Havana | 682 nt | ||
| mRNA | ottdart00000001848 (1) | Havana | 1,706 nt | ||
| mRNA | ottdart00000056007 (1) | Havana | 1,527 nt | ||
| mRNA |
stat1b-201
(1)
|
Ensembl | 4,113 nt | ||
| mRNA |
stat1b-202
(1)
|
Ensembl | 535 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(stat1b:lck-mScarletI,cryaa:mScarletI) |
|
| 1 | Denans et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196J1 | ZFIN Curated Data | |
| Contained in | BAC | IZAB-51F19 | ZFIN Curated Data | |
| Contained in | BAC | IZAB-85C7 | ZFIN Curated Data | |
| Contained in | BAC | XX-BY134G18 | ||
| Contained in | PAC | BUSM1-73O4 | ||
| Contained in | PAC | BUSM1-87I4 | ||
| Contained in | PAC | BUSM1-199M19 | ||
| Encodes | EST | fi49f02 | ||
| Encodes | cDNA | MGC:55503 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200091 (1) | 4113 nt | ||
| Genomic | GenBank:BX649377 (1) | 217898 nt | ||
| Polypeptide | UniProtKB:B0S789 (1) | 725 aa |
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Bernal-Bermúdez, B., Martínez-López, A., Martínez-Morcillo, F.J., Tyrkalska, S.D., Martínez-Menchón, T., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V., García-Moreno, D. (2023) A zebrafish model of Ifih1-driven Aicardi-Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients. Frontiers in immunology. 14:12947661294766
- Withers, S.E., Rowlands, C.F., Tapia, V.S., Hedley, F., Mosneag, I.E., Crilly, S., Rice, G.I., Badrock, A.P., Hayes, A., Allan, S.M., Briggs, T.A., Kasher, P.R. (2023) Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome. Frontiers in immunology. 14:11009671100967
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Huang, W., Zhao, X., Ji, N., Guo, J., Feng, J., Chen, K., Wu, Y., Wang, J., Feng, H., Zou, J. (2022) IRF2 Cooperates with Phosphoprotein of Spring Viremia of Carp Virus to Suppress Antiviral Response in Zebrafish. Journal of virology. 96(22):e0131422
- Wang, Y.Y., Nie, L., Xu, X.X., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Essential Role of RIG-I in Hematopoietic Precursor Emergence in Primitive Hematopoiesis during Zebrafish Development. ImmunoHorizons. 6:283-298
- Seese, S.E., Deml, B., Muheisen, S., Sorokina, E., Semina, E.V. (2021) Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(8):1056-1073
- Zang, L., Shimada, Y., Nakayama, H., Katsuzaki, H., Kim, Y., Chu, D.C., Juneja, L.R., Kuroyanagi, J., Nishimura, N. (2021) Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish. Molecules. 26(9):
- Zhang, X.Y., Liu, Y.H., Liu, D.Z., Xu, J.Y., Zhang, Q. (2021) Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics. Pharmaceuticals (Basel, Switzerland). 14(7):
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