Gene
szl
- ID
- ZDB-GENE-030530-1
- Name
- sizzled
- Symbol
- szl Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including determination of dorsal identity; negative regulation of BMP signaling pathway; and protein stabilization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ectoderm; mesoderm; periderm; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu695 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Netrin domain |
---|---|---|---|---|---|---|
UniProtKB:Q7SX78 | InterPro | 282 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Encodes | EST | eu695 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:136522 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_181663 (1) | 1508 nt | ||
Genomic | GenBank:CU929174 (1) | 36035 nt | ||
Polypeptide | UniProtKB:Q7SX78 (1) | 282 aa |
- Greenfeld, H., Lin, J., Mullins, M.C. (2021) The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biology. 19:e3001059
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Tuazon, F.B., Wang, X., Andrade, J.L., Umulis, D., Mullins, M.C. (2020) Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Reports. 32:108039
- Vonica, A., Bhat, N., Phan, K., Guo, J., Iancu, L., Weber, J.A., Karger, A., Cain, J.W., Wang, E.C.E., DeStefano, G.M., O'Donnell-Luria, A.H., Christiano, A.M., Riley, B., Butler, S.J., Luria, V. (2020) Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin. Developmental Biology. 464(1):71-87
- Kansara, K., Kumar, A., Karakoti, A.S. (2019) Combination of humic acid and clay reduce the ecotoxic effect of TiO2 NPs: A combined physico-chemical and genetic study using zebrafish embryo. The Science of the total environment. 698:134133
- Kansara, K., Paruthi, A., Misra, S.K., Karakoti, A.S., Kumar, A. (2019) Montmorillonite clay and humic acid modulate the behavior of copper oxide nanoparticles in aqueous environment and induces developmental defects in zebrafish embryo. Environmental pollution (Barking, Essex : 1987). 255:113313
- Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
- Speer, K.F., Sommer, A., Tajer, B., Mullins, M.C., Klein, P.S., Lemmon, M.A. (2019) Non-acylated Wnts Can Promote Signaling. Cell Reports. 26:875-883.e5
- Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., Sun, Y. (2019) Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLoS Genetics. 15:e1008306
- Abe, G., Lee, S.H., Li, I.J., Ota, K.G. (2018) An alternative evolutionary pathway for the twin-tail goldfish via szl gene mutation. Journal of experimental zoology. Part B, Molecular and developmental evolution. 330:234-241
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