Gene
cmlc1
- ID
- ZDB-GENE-030522-1
- Name
- cardiac myosin light chain-1
- Symbol
- cmlc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within heart contraction; heart morphogenesis; and myofibril assembly. Predicted to be part of myosin II complex. Is expressed in cardiac muscle myoblast; heart primordium; mesoderm; pericardial region; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cmlc1 | Takada et al., 2017 | |
| CRISPR2-cmlc1 | Ghazizadeh et al., 2019 | |
| CRISPR3-cmlc1 | Ghazizadeh et al., 2019 | |
| MO1-cmlc1 | N/A | Chen et al., 2008 |
| MO2-cmlc1 | N/A | (4) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calmodulin/Myosin light chain/Troponin C-like | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|
| UniProtKB:A0A8N7UZM3 | InterPro | 196 | |||
| UniProtKB:Q5XJC3 | InterPro | 196 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(kop:mCherryF-nanos3-UTR,cmlc1:EGFP) |
|
| 1 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-43F11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6903402 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:103441 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192170 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131692 (1) | 800 nt | ||
| Genomic | GenBank:AL845516 (1) | 205826 nt | ||
| Polypeptide | UniProtKB:A0A8N7UZM3 (1) | 196 aa |
No data available
- Hofeichner, J., Gahr, B.M., Huber, M., Boos, A., Rottbauer, W., Just, S. (2023) CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Scientific Reports. 13:2267922679
- Müller, M., Eghbalian, R., Boeckel, J.N., Frese, K.S., Haas, J., Kayvanpour, E., Sedaghat-Hamedani, F., Lackner, M.K., Tugrul, O.F., Ruppert, T., Tappu, R., Martins Bordalo, D., Kneuer, J.M., Piekarek, A., Herch, S., Schudy, S., Keller, A., Grammes, N., Bischof, C., Klinke, A., Cardoso-Moreira, M., Kaessmann, H., Katus, H.A., Frey, N., Steinmetz, L.M., Meder, B. (2022) NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nature communications. 13:6209
- An, H.J., Lee, Y.J., Choe, C.P., Cho, H.K., Song, D.H. (2021) Long noncoding RNAs associated with nonalcoholic fatty liver disease in a high cholesterol diet adult zebrafish model. Scientific Reports. 11:23005
- Bühler, A., Gahr, B.M., Park, D.D., Bertozzi, A., Boos, A., Dalvoy, M., Pott, A., Oswald, F., Kovall, R.A., Kühn, B., Weidinger, G., Rottbauer, W., Just, S. (2021) Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish. PLoS Genetics. 17:e1009890
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Ma, A.C.H., Mak, C.C.Y., Yeung, K.S., Pei, S.L.C., Ying, D., Yu, M.H.C., Hasan, K.M.M., Chen, X., Chow, P.C., Cheung, Y.F., Chung, B.H.Y. (2020) Mono-allelic Mutations in CC2D1A Suggest a Novel Role in Human Heterotaxy and Ciliary Dysfunction. Circulation. Genomic and precision medicine. 13(6):e003000
- Mu, X., Chen, X., Liu, J., Yuan, L., Wang, D., Qian, L., Qian, Y., Shen, G., Huang, Y., Li, X., Li, Y., Lin, X. (2020) A multi-omics approach reveals molecular mechanisms by which phthalates induce cardiac defects in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:113876
- Ben-Yair, R., Butty, V.L., Busby, M., Qiu, Y., Levine, S.S., Goren, A., Boyer, L.A., Burns, C.G., Burns, C.E. (2019) H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development (Cambridge, England). 146(19):
- Ghazizadeh, Z., Kiviniemi, T.O., Olafsson, S., Plotnick, D., Beerens, M., Zhang, K., Gillon, L., Steinbaugh, M., Barrera, V., Ho Sui, S., Werdich, A.A., Kapur, S., Eranti, A., Gunn, J., Jalkanen, J., Airaksinen, J., Kleber, A.G., Hollmén, M., MacRae, C.A. (2019) A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation. Circulation. 141(4):301-312
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