Gene
cdkn1bb
- ID
- ZDB-GENE-030521-13
- Name
- cyclin dependent kinase inhibitor 1Bb
- Symbol
- cdkn1bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein-folding chaperone binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; and negative regulation of mitotic cell cycle. Predicted to be located in endosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; nervous system; pectoral fin; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb611 (12 images)
- IMAGE:7152670 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nc100 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdkn1bb | (3) | |
| CRISPR2-cdkn1bb | (3) | |
| MO1-cdkn1bb | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple endocrine neoplasia type 4 | Alliance | Multiple endocrine neoplasia, type IV | 610755 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase inhibitor domain | Cyclin-dependent kinase inhibitor domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q90YX4 | InterPro | 179 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkn1bb-201
(1)
|
Ensembl | 1,921 nt | ||
| ncRNA |
cdkn1bb-002
(1)
|
Ensembl | 864 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218P2 | ZFIN Curated Data | |
| Encodes | EST | cb611 | Thisse et al., 2001 | |
| Encodes | EST | fb63g10 | ZFIN Curated Data | |
| Encodes | EST | fb64g10 | ||
| Encodes | EST | fe18e03 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7152670 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:65754 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77582 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212792 (1) | 1880 nt | ||
| Genomic | GenBank:CR354430 (2) | 197231 nt | ||
| Polypeptide | UniProtKB:Q90YX4 (1) | 179 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhang, J., Li, P., Sun, L., Jiang, N., Guo, W., Wang, J., Gao, F., Li, J., Li, H., Zhang, J., Mu, H., Hu, Y., Cui, X. (2023) Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22927e22927
- Wang, C., Zhang, X., Wang, X., Zhai, Y., Li, M., Pan, J., Bai, Y., Rong, X., Zhou, J. (2022) Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development. Journal of Cell Science. 135(21):
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Jerafi-Vider, A., Bassi, I., Moshe, N., Tevet, Y., Hen, G., Splittstoesser, D., Shin, M., Lawson, N.D., Yaniv, K. (2021) VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Reports. 35:109255
- Yang, L., Webb, S.E., Jin, N., Lee, H.M., Chan, T.F., Xu, G., Chan, J.C.N., Miller, A.L., Ma, R.C.W. (2021) Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Journal of diabetes investigation. 12(5):710-727
- Erbaba, B., Burhan, Ö.P., Şerifoğlu, N., Muratoğlu, B., Kahveci, F., Adams, M.M., Arslan-Ergül, A. (2020) Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. Neurobiology of aging. 94:164-175
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