Gene
nrarpa
- ID
- ZDB-GENE-030515-6
- Name
- NOTCH regulated ankyrin repeat protein a
- Symbol
- nrarpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including angiogenesis; neural crest cell migration; and pigment cell differentiation. Is expressed in several structures, including germ ring; pronephros; segmental plate; somite border; and trunk vasculature. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138364 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Protein Phosphatase 1 Regulatory Subunit |
|---|---|---|---|---|---|
| UniProtKB:Q7T3Y0 | InterPro | 112 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrarpa-201
(1)
|
Ensembl | 3,495 nt | ||
| mRNA |
nrarpa-202
(1)
|
Ensembl | 3,178 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-21P9 | ZFIN Curated Data | |
| Encodes | EST | fa14d10 | ||
| Encodes | EST | fc89b12 | ||
| Encodes | EST | ibd2282 | ||
| Encodes | EST | IMAGE:7138364 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100826 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181495 (1) | 3193 nt | ||
| Genomic | GenBank:BX005370 (1) | 208765 nt | ||
| Polypeptide | UniProtKB:Q7T3Y0 (1) | 112 aa |
- Li, G.X., Zhang, S., Liu, R., Singh, B., Singh, S., Quinn, D.I., Crump, G., Gill, P.S. (2020) Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 10(2):
- Nitzan, M., Karaiskos, N., Friedman, N., Rajewsky, N. (2019) Gene expression cartography. Nature. 576(7785):132-137
- You, M.S., Wang, W.P., Wang, J.Y., Jiang, Y.J., Chi, Y.H. (2019) Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish. Stem cells and development. 28(16):1116-1127
- Jagadeeshan, S., Sagayaraj, R.V., Paneerselvan, N., Ghouse, S.S., Malathi, R. (2017) Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. 33(1):41-56
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Huang, X., Zhao, Y., Liu, L., Fan, Z., Zhou, L., Wang, Z., Wei, L., Wang, D., Wei, J. (2016) Characterization of the POU5F1 homologue in Nile tilapia: from expression pattern to biological activity. Stem cells and development. 25(18):1386-95
- Katz, S., Cussigh, D., Urbán, N., Blomfield, I., Guillemot, F., Bally-Cuif, L., Coolen, M. (2016) A Nuclear Role for miR-9 and Argonaute Proteins in Balancing Quiescent and Activated Neural Stem Cell States. Cell Reports. 17:1383-1398
- Liu, L.Y., Lin, M.H., Lai, Z.Y., Jiang, J.P., Huang, Y.C., Jao, L.E., Chuang, Y.J. (2016) Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. Journal of Biomedical Science. 23:59
- Coxam, B., Neyt, C., Grassini, D.R., Le Guen, L., Smith, K.A., Schulte-Merker, S., Hogan, B.M. (2015) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(1):1-9
- Satija, R., Farrell, J.A., Gennert, D., Schier, A.F., Regev, A. (2015) Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol.. 33(5):495-502
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