Gene
otx5
- ID
- ZDB-GENE-030508-1
- Name
- orthodenticle homolog 5
- Symbol
- otx5 Nomenclature History
- Previous Names
-
- cb828 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within circadian regulation of gene expression and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in forebrain; optic vesicle; and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 84 figures from 56 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb828 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cone-rod dystrophy 2 | Alliance | Cone-rod retinal dystrophy-2 | 120970 |
| Leber congenital amaurosis 7 | Alliance | Leber congenital amaurosis 7 | 613829 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Transcription factor Otx | Transcription factor Otx, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYT9 | InterPro | 289 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-111C8 | ZFIN Curated Data | |
| Encodes | EST | cb828 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:65752 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76843 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181331 (1) | 1877 nt | ||
| Genomic | GenBank:CU633848 (1) | 35813 nt | ||
| Polypeptide | UniProtKB:Q6NYT9 (1) | 289 aa |
- Chen, B., Ran, Q., Chen, X., Deng, Z., Zhou, R., Zhang, Y., Liu, M., Li, B., Huang, S., Wang, P., Huang, S. (2024) Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish. Biochemistry and biophysics reports. 39:101782101782
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Veen, K., Krylov, A., Yu, S., He, J., Boyd, P., Hyde, D.R., Mantamadiotis, T., Cheng, L.Y., Jusuf, P.R. (2023) Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genetics. 19:e1011010e1011010
- Agostini, C., Bühler, A., Antico Calderone, A., Aadepu, N., Herder, C., Loosli, F., Carl, M. (2022) Conserved and diverged asymmetric gene expression in the brain of teleosts. Frontiers in cell and developmental biology. 10:1005776
- Bortolin-Cavaillé, M.L., Aurélie, Q., Supuni, T.G., Thomas, J.M., Sas-Chen, A., Sharma, S., Plisson-Chastang, C., Vandel, L., Blader, P., Lafontaine, D.L.J., Schwartz, S., Meier, J.L., Cavaillé, J. (2022) Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution. Nucleic acids research. 50(11):6284-6299
- Carstensen, M.B., Medvetzky, A., Weinberger, A., Driever, W., Gothilf, Y., Rath, M.F. (2022) Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior. Journal of pineal research. 72(4):e12795
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., Wang, C. (2020) Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. Journal of hazardous materials. 404:124083
- Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774
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