Gene
plcg1
- ID
- ZDB-GENE-030421-3
- Name
- phospholipase C, gamma 1
- Symbol
- plcg1 Nomenclature History
- Previous Names
-
- dead beat
- ded
- fj46f04
- wu:fj46f04 (1)
- wu:fj57a05
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Acts upstream of or within several processes, including blood vessel morphogenesis; fin regeneration; and hemopoiesis. Predicted to be located in cytoplasm; lamellipodium; and ruffle. Predicted to be active in ruffle membrane. Is expressed in brain; heart; intermediate cell mass of mesoderm; ovary; and vasculature. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 31 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2335Tg | Transgenic insertion | Intron 3 | Unknown | DNA | |
| hi3479Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022620Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m582 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| rj100 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t26480 | Allele with one point mutation | Unknown | Unknown | not specified | |
| y10 | Allele with one point mutation | Acceptor Splice Site | Splice Site | ENU | |
| y13 | Allele with one point mutation | Unknown | Missense | ENU | |
| y15 | Allele with one point mutation | Unknown | Unknown | ENU | |
| y16 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Immune dysregulation, autoimmunity, and autoinflammation | 620514 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain | C2 domain | C2 domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-gamma, C-terminal SH2 domain | PLC-gamma, N-terminal SH2 domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q804J6 | InterPro | 1312 |
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Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-154M12 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-161C3 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-213L17 | ZFIN Curated Data | |
| Encodes | EST | fj46f04 | ZFIN Curated Data | |
| Encodes | EST | fj57a05 | ||
| Encodes | cDNA | MGC:194052 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194407 (1) | 4103 nt | ||
| Genomic | GenBank:CU633907 (2) | 38805 nt | ||
| Polypeptide | UniProtKB:Q804J6 (1) | 1312 aa |
- Bastos de Oliveira, M., Meier, K., Jung, S., Bartels-Klein, E., Coxam, B., Geudens, I., Szymborska, A., Skoczylas, R., Fechner, I., Koltowska, K., Gerhardt, H. (2021) Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development (Cambridge, England). 148(4):
- Djenoune, L., Tomar, R., Dorison, A., Ghobrial, I., Schenk, H., Hegermann, J., Beverly-Staggs, L., Hidalgo-Gonzalez, A., Little, M.H., Drummond, I.A. (2021) Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. Journal of the American Society of Nephrology : JASN. 32(7):1697-1712
- Mauri, C., van Impel, A., Mackay, E.W., Schulte-Merker, S. (2021) The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk. Angiogenesis. 24(2):345-362
- Chen, B., Zheng, Y.M., Zhang, M.Q., Han, Y., Zhang, J.P., Hu, C.Q. (2020) Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model. Frontiers in pharmacology. 10:1504
- Stratman, A.N., Farrelly, O.M., Mikelis, C.M., Miller, M.F., Wang, Z., Pham, V.N., Davis, A.E., Burns, M.C., Pezoa, S.A., Castranova, D., Yano, J.J., Kilts, T.M., Davis, G.E., Gutkind, J.S., Weinstein, B.M. (2020) Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Nature communications. 11:1204
- Ferri-Lagneau, K.F., Haider, J., Sang, S., Leung, T. (2019) Rescue of hematopoietic stem/progenitor cells formation in plcg1 zebrafish mutant. Scientific Reports. 9:244
- Hsu, J.J., Vedula, V., Baek, K.I., Chen, C., Chen, J., Chou, M.I., Lam, J., Subhedar, S., Wang, J., Ding, Y., Chang, C.C., Lee, J., Demer, L.L., Tintut, Y., Marsden, A.L., Hsiai, T.K. (2019) Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. JCI insight. 5(10):
- Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., Xue, W., Wu, S., Cao, M., Fu, C., Qi, H., Hao, Y., Tang, Y.C., Qin, J., Zhong, T.P., Lin, X., Yu, L., Li, X., Li, L., Wu, D., Pan, W. (2019) Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research. 29(11):895-910
- Lausser, L., Siegle, L., Rottbauer, W., Frank, D., Just, S., Kestler, H.A. (2018) Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species. Biomolecules. 8(4):
- Nayak, S., Khozin-Goldberg, I., Cohen, G., Zilberg, D. (2018) Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection. Frontiers in immunology. 9:1960
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