Gene
plcg1
- ID
- ZDB-GENE-030421-3
- Name
- phospholipase C, gamma 1
- Symbol
- plcg1 Nomenclature History
- Previous Names
-
- dead beat
- ded
- fj46f04
- wu:fj46f04 (1)
- wu:fj57a05
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Acts upstream of or within several processes, including blood vessel morphogenesis; fin regeneration; and hemopoiesis. Predicted to be located in cytoplasm; lamellipodium; and ruffle. Predicted to be active in ruffle membrane. Is expressed in brain; heart; intermediate cell mass of mesoderm; ovary; and vasculature. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 31 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Immune dysregulation, autoimmunity, and autoinflammation | 620514 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR035023 | PLC-gamma, C-terminal SH2 domain |
| Domain | IPR035024 | PLC-gamma, N-terminal SH2 domain |
| Domain | IPR035724 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain |
| Family | IPR001192 | Phosphoinositide phospholipase C family |
| Family | IPR016279 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain | C2 domain | C2 domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-gamma, C-terminal SH2 domain | PLC-gamma, N-terminal SH2 domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q804J6 | InterPro | 1312 |
Interactions and Pathways
Plasmids