Gene

plcg1

ID
ZDB-GENE-030421-3
Name
phospholipase C, gamma 1
Symbol
plcg1 Nomenclature History
Previous Names
  • dead beat
  • ded
  • fj46f04
  • wu:fj46f04 (1)
  • wu:fj57a05
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Acts upstream of or within several processes, including blood vessel morphogenesis; fin regeneration; and hemopoiesis. Predicted to be located in cytoplasm; lamellipodium; and ruffle. Predicted to be active in ruffle membrane. Is expressed in brain; heart; intermediate cell mass of mesoderm; ovary; and vasculature. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
31 figures from 19 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi2335TgTransgenic insertionIntron 3UnknownDNA
hi3479TgTransgenic insertionUnknownUnknownDNA
la022620TgTransgenic insertionUnknownUnknownDNA
m582Allele with one point mutationUnknownPremature StopENU
rj100Allele with one point mutationUnknownPremature StopENU
t26480Allele with one point mutationUnknownUnknownnot specified
y10Allele with one point mutationAcceptor Splice SiteSplice SiteENU
y13Allele with one point mutationUnknownMissenseENU
y15Allele with one point mutationUnknownUnknownENU
y16Allele with one point mutationUnknownUnknownENU
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Sequence Targeting Reagents
Human Disease
Associated With plcg1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Immune dysregulation, autoimmunity, and autoinflammation 620514
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Associated With plcg1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR000008 C2 domain
Domain IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
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Domain Details Per Protein
Protein Additional Resources Length 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain C2 domain C2 domain superfamily EF-Hand 1, calcium-binding site EF-hand domain pair PH-like domain superfamily Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma Phosphatidylinositol-specific phospholipase C, X domain Phosphoinositide phospholipase C family Phospholipase C, phosphatidylinositol-specific, Y domain PLC-gamma, C-terminal SH2 domain PLC-gamma, N-terminal SH2 domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily Pleckstrin homology domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily
UniProtKB:Q804J6 InterPro 1312
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 23
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA plcg1-201 (1) Ensembl 5,161 nt
mRNA plcg1-202 (1) Ensembl 407 nt
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Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-154M12ZFIN Curated Data
Contained inFosmidCH1073-161C3ZFIN Curated Data
Contained inFosmidCH1073-213L17ZFIN Curated Data
EncodesESTfj46f04ZFIN Curated Data
EncodesESTfj57a05
EncodescDNAMGC:194052ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPLCG120
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MousePlcg12
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 54
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