Gene
gpx1a
- ID
- ZDB-GENE-030410-1
- Name
- glutathione peroxidase 1a
- Symbol
- gpx1a Nomenclature History
- Previous Names
-
- gpx1
- cb690 (1)
- zgc:103683
- zgc:92737
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity. Predicted to be involved in several processes, including hydrogen peroxide catabolic process; response to hydrogen peroxide; and response to selenium ion. Predicted to act upstream of or within response to oxidative stress. Predicted to be active in cytosol and mitochondrion. Is expressed in Kupffer's vesicle; digestive system; female organism; muscle; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb690 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017876Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hemolytic anemia due to glutathione peroxidase deficiency | 614164 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione peroxidase | Glutathione peroxidase active site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q5XJ48 | InterPro | 142 | |||
| UniProtKB:A0A8M1N370 | InterPro | 191 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51M8 | ZFIN Curated Data | |
| Contains | STS | unp1670 | ||
| Encodes | EST | cb690 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92737 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103683 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191965 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007281 (1) | 1004 nt | ||
| Genomic | GenBank:CR933559 (2) | 119833 nt | ||
| Polypeptide | UniProtKB:A0A8M1N370 (1) | 191 aa |
- Katoch, S., Chhimwal, J., Singh, D., Kumar, D., Patial, V. (2025) Picrosides-rich fraction from Picrorhiza kurroa attenuates steatohepatitis in zebrafish and mice by modulating lipid metabolism and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 137:156368156368
- Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., Xue, C. (2025) Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos. Food research international (Ottawa, Ont.). 200:115502115502
- Harijan, A.K., Kalaiarasan, R., Ghosh, A.K., Jain, R.P., Bera, A.K. (2024) The neuroprotective effect of short-chain fatty acids against hypoxia-reperfusion injury. Molecular and cellular neurosciences. 131:103972
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Lin, W., Hu, F., Zou, W., Wang, S., Shi, P., Li, L., Yang, J., Yang, P. (2024) Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway. toxins. 16(12):
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Gómez Sánchez, A., Colucci, P., Moran, A., Moya López, A., Colligris, B., Álvarez, Y., Kennedy, B.N. (2023) Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis. Open research Europe. 3:4848
- Li, X., Zeng, L., Qu, Z., Zhang, F. (2023) Huoxin pill protects verapamil-induced zebrafish heart failure through inhibition of oxidative stress-triggered inflammation and apoptosis. Heliyon. 10:e23402e23402
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