Gene
mib1
- ID
- ZDB-GENE-030404-2
- Name
- MIB E3 ubiquitin protein ligase 1
- Symbol
- mib1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Contributes to ubiquitin-protein transferase activity. Acts upstream of or within several processes, including nervous system development; sensory system development; and tube morphogenesis. Located in endocytic vesicle and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in blood vessel; embryonic structure; nervous system; neural tube; and pectoral fin. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 143 figures from 85 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi904Tg | Transgenic insertion | Exon 4 | Unknown | DNA | |
| m132 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m178 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| mib1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| nce2a | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| nn2000 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| nn2001 | Allele with one insertion | Unknown | Unknown | ENU | |
| sa31118 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44378 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ta52b | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Left ventricular noncompaction 7 | 615092 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | mib1hi904Tg/hi904Tg | standard conditions | Hortopan et al., 2010 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type | Mib-herc2 | Mib/herc2 domain superfamily | Mind bomb, SH3 repeat domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:H9GYU5 | InterPro | 1041 | ||||||||||
| UniProtKB:A0A8M3AMW2 | InterPro | 1017 | ||||||||||
| UniProtKB:Q804S5 | InterPro | 1030 | ||||||||||
| UniProtKB:A0A8M3AVC7 | InterPro | 1006 | ||||||||||
| UniProtKB:A0A8M3AMW8 | InterPro | 1006 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(col2a1a:mib_M1013R) |
|
| 1 | (2) | |
| Tg(hsp70l-mib1:EGFP) |
|
| 2 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-2P18 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-221A23 | ZFIN Curated Data | |
| Encodes | EST | eu763 | Thisse et al., 2005 | |
| Encodes | EST | fe47f05 | ||
| Encodes | EST | IMAGE:7148100 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:193576 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173286 (1) | 3293 nt | ||
| Genomic | GenBank:BX842700 (2) | 198258 nt | ||
| Polypeptide | UniProtKB:H9GYU5 (1) | 1041 aa |
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Prendergast, A., Ziganshin, B.A., Papanikolaou, D., Zafar, M.A., Nicoli, S., Mukherjee, S., Elefteriades, J.A. (2022) Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm. Genes. 13(1):
- Saraswathy, V.M., Kurup, A.J., Sharma, P., Polès, S., Poulain, M., Fürthauer, M. (2022) The E3 Ubiquitin Ligase Mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. eLIFE. 11:
- Zhao, F., He, J., Tang, J., Cui, N., Shi, Y., Li, Z., Liu, S., Wang, Y., Ma, M., Zhao, C., Luo, L., Li, L. (2022) Brain milieu induces early microglial maturation through the BAX-Notch axis. Nature communications. 13:6117
- Zhao, S., Feng, S., Tian, Y., Wen, Z. (2022) Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. Proceedings of the National Academy of Sciences of the United States of America. 119:e2119051119e2119051119
- Juárez-Morales, J.L., Weierud, F., England, S.J., Demby, C., Santos, N., Grieb, G., Mazan, S., Lewis, K.E. (2021) Evolution of lbx spinal cord expression and function. Evolution & development. 23(5):404-422
- Lu, Y.F., Liu, D.W., Li, I.C., Lin, J., Wang, C.M., Chu, K.C., Kuo, H.H., Lin, C.Y., Yih, L.H., Jiang, Y.J., Hwang, S.L. (2021) Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos. PLoS Genetics. 17:e1009969
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