Gene
p2rx3b
- ID
- ZDB-GENE-030319-3
- Name
- purinergic receptor P2X, ligand-gated ion channel, 3b
- Symbol
- p2rx3b Nomenclature History
- Previous Names
-
- zP2X3.2 (1)
- zgc:110486
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables extracellularly ATP-gated monoatomic cation channel activity. Acts upstream of or within monoatomic cation transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in Rohon-Beard neurons; cranial ganglion; and trigeminal ganglion. Orthologous to human P2RX3 (purinergic receptor P2X 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1216 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31226 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31227 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko846a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko846b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP P2X receptor, conserved site | P2X3 purinoceptor | P2X purinoreceptor | P2X purinoreceptor extracellular domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PCJ8 | InterPro | 412 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
p2rx3b-201
(1)
|
Ensembl | 2,930 nt | ||
| ncRNA |
p2rx3b-002
(1)
|
Ensembl | 759 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4p2rx3b:GAL4-VP16,myl7:CFP) |
|
| 1 | (5) | |
| Tg(p2rx3b-E1B:LEXA-VP16,LEXOP-E1B:Hsa.MAPRE3-GFP) |
| 1 | (3) | ||
| Tg(p2rx3b:EGFP) |
|
| 1 | (20) | |
| Tg(p2rx3b:GCaMP6s,myl7:EGFP) |
|
| 1 | Pan et al., 2022 | |
| Tg(p2rx3b:NTR-mCherry) |
|
| 1 | Cox et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28B4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110486 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198986 (1) | 2930 nt | ||
| Genomic | GenBank:BX511158 (1) | 198706 nt | ||
| Polypeptide | UniProtKB:A0A8M9PCJ8 (1) | 412 aa |
- Brown, T.L., Horton, E.C., Craig, E.W., Goo, C.E.A., Black, E.C., Hewitt, M.N., Yee, N.G., Fan, E.T., Raible, D.W., Rasmussen, J.P. (2023) Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells. eLIFE. 12:
- Pan, Y.K., Julian, T., Garvey, K., Perry, S.F. (2022) Catecholamines modulate the hypoxic ventilatory response of larval zebrafish (Danio rerio). The Journal of experimental biology. 226(1):
- Cox, J.A., Voigt, M.M. (2019) The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain. Frontiers in neural circuits. 13:14
- Feng, C., Thyagarajan, P., Shorey, M., Seebold, D.Y., Weiner, A.T., Albertson, R.M., Rao, K.S., Sagasti, A., Goetschius, D.J., Rolls, M.M. (2019) Patronin-mediated minus end growth is required for dendritic microtubule polarity. The Journal of cell biology. 218(7):2309-2328
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Astone, M., Pizzi, M., Peron, M., Domenichini, A., Guzzardo, V., Töchterle, S., Tiso, N., Rugge, M., Meyer, D., Argenton, F., Vettori, A. (2015) A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish. PLoS One. 10:e0145178
- Pan, Y.A., Choy, M., Prober, D.A., and Schier, A.F. (2012) Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development (Cambridge, England). 139(3):591-600
- Kucenas, S., Cox, J.A., Soto, F., Lamora, A., and Voigt, M.M. (2009) Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish. Purinergic signalling. 5(3):395-407
- Lamora, A., and Voigt, M.M. (2009) Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targets. Neuroscience. 159(3):1175-1184
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