Gene
tph1a
- ID
- ZDB-GENE-030317-1
- Name
- tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
- Symbol
- tph1a Nomenclature History
- Previous Names
-
- tph1-1 (1)
- tph1
- tph
- tphD1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and heroin dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73202 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb752 | Allele with one deletion | Exon 7 | Unknown | CRISPR | |
| ihb753 | Allele with one deletion | Exon 7 | Unknown | CRISPR | |
| ot203 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ot204 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa24612 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38011 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tph1a | Hwang et al., 2013 | |
| CRISPR2-tph1a | (4) | |
| CRISPR3-tph1a | Zebrafish Nomenclature Committee | |
| MO1-tph1a | N/A | Kwan et al., 2016 |
| MO2-tph1a | N/A | Pan et al., 2020 |
| TALEN1-tph1a | Hwang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR002912 | ACT domain |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041904 | Tryptophan 5-hydroxylase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ACT domain | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tryptophan 5-hydroxylase, catalytic domain | Tryptophan 5-monooxygenase | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YYD4 | InterPro | 477 | ||||||||||
| UniProtKB:Q6PBX4 | InterPro | 483 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(tph1a:mCherry,myl7:EGFP) |
|
| 1 | Pan et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-47K21 | ZFIN Curated Data | |
| Contained in | BAC | CH73-334L12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-146D6 | ||
| Encodes | cDNA | MGC:73202 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178306 (1) | 1709 nt | ||
| Genomic | GenBank:BX001042 (1) | 168195 nt | ||
| Polypeptide | UniProtKB:Q6PBX4 (1) | 483 aa |
- Kroll, F., Donnelly, J., Özcan, G.G., Mackay, E., Rihel, J. (2025) Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes. eLIFE. 13:
- Rajeswari, J.J., Gilbert, G.N.Y., Khalid, E., Vijayan, M.M. (2025) Brain monoamine changes modulate the corticotropin-releasing hormone receptor 1-mediated behavioural response to acute thermal stress in zebrafish larvae. Molecular and Cellular Endocrinology. :112494112494
- Correia, D., Bellot, M., Goyenechea, J., Prats, E., Moro, H., Gómez-Canela, C., Bedrossiantz, J., Tagkalidou, N., Ferreira, C.S.S., Raldúa, D., Domingues, I., Faria, M., Oliveira, M. (2024) Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish. Chemosphere. 355:141851
- Godino-Gimeno, A., Rocha, A., Chivite, M., Saera-Vila, A., Rotllant, J., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Agouti-induced anxiety-like behaviour is mediated by central serotonergic pathways in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(32):
- Lee, J.H., Hwang, S.J., Ham, S.L., Kim, J., Bang, H.J., Park, J.S., Jang, H.H., Kim, T.Y., Park, J.W., Seo, Y.R., Kim, B.S., Kim, G.S., Lee, H.J., Kim, C.S. (2024) Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice. ACS omega. 9:438754388343875-43883
- Miyazaki, S., Shimizu, N., Miyahara, H., Teranishi, H., Umeda, R., Yano, S., Shimada, T., Shiraishi, H., Komiya, K., Katoh, A., Yoshimura, A., Hanada, R., Hanada, T. (2024) DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and Biophysical Research Communications. 712-713:149932149932
- Tea, M., Pan, Y.K., Lister, J.G.R., Perry, S.F., Gilmour, K.M. (2024) Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 210(5):785-799
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Araujo-Silva, H., de Souza, A.M., Mamede, J.P.M., Batistuzzo de Medeiros, S.R., Luchiari, A.C. (2023) Individual differences in response to alcohol and nicotine in zebrafish: gene expression and behavior. Development, growth & differentiation. 65(8):434-445
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
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