Gene
zic2b
- ID
- ZDB-GENE-030219-92
- Name
- zic family member 2 (odd-paired homolog, Drosophila) b
- Symbol
- zic2b Nomenclature History
- Previous Names
-
- zic2.2 (1)
- zic2l
- hm:zeh0655
- id:ibd5017
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including brain development; embryonic viscerocranium morphogenesis; and regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Teslaa et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028121Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028122Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa32696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uw1116 | Allele with one insertion | Unknown | Frameshift | CRISPR | |
| uw1127 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| uwt104 | Allele with one deletion | Unknown | Frameshift | TALEN | |
| zko571a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 5 | Alliance | Holoprosencephaly 5 | 609637 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type zinc-finger protein GLI-like | ZIC1-5/GLI1-3like, C2H2 zinc finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DE40 | InterPro | 427 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-256M19 | ZFIN Curated Data | |
| Contains | SNP | rs3727533 | ZFIN Curated Data | |
| Contains | SNP | rs3727534 | ZFIN Curated Data | |
| Encodes | EST | ibd5017 | ||
| Encodes | EST | zeh0655 | ||
| Encodes | cDNA | MGC:110428 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198352 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198356 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001820 (1) | 2239 nt | ||
| Genomic | GenBank:BX088652 (2) | 161341 nt | ||
| Polypeptide | UniProtKB:Q9DE40 (1) | 427 aa |
- Okada, K., Aoki, K., Tabei, T., Sugio, K., Imai, K., Bonkohara, Y., Kamachi, Y. (2022) Key sequence features of CRISPR RNA for dual-guide CRISPR-Cas9 ribonucleoprotein complexes assembled with wild-type or HiFi Cas9. Nucleic acids research. 50(5):2854-2871
- Hilbert, L., Sato, Y., Kuznetsova, K., Bianucci, T., Kimura, H., Jülicher, F., Honigmann, A., Zaburdaev, V., Vastenhouw, N.L. (2021) Transcription organizes euchromatin via microphase separation. Nature communications. 12:1360
- Jung, J., Kim, E., Rhee, M. (2021) Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos. Molecules and cells. 44(4):233-244
- Vigouroux, R.J., Duroure, K., Vougny, J., Albadri, S., Kozulin, P., Herrera, E., Nguyen-Ba-Charvet, K., Braasch, I., Suárez, R., Del Bene, F., Chédotal, A. (2021) Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods. Science (New York, N.Y.). 372:150-156
- Marass, M., Beisaw, A., Gerri, C., Luzzani, F., Fukuda, N., Günther, S., Kuenne, C., Reischauer, S., Stainier, D.Y.R. (2019) Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish. Development (Cambridge, England). 146(11):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Kaur, S., Gupta, S., Chaudhary, M., Khursheed, M.A., Mitra, S., Kurup, A.J., Ramachandran, R. (2018) let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration. Cell Reports. 23:1409-1423
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Sedykh, I., Yoon, B., Roberson, L., Moskvin, O., Dewey, C.N., Grinblat, Y. (2017) Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis. Developmental Biology. 429(1):92-104
- Stapel, L.C., Zechner, C., Vastenhouw, N.L. (2017) Uniform gene expression in embryos is achieved by temporal averaging of transcription noise. Genes & Development. 31(16):1635-1640
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