Gene
copb1
- ID
- ZDB-GENE-030219-38
- Name
- COPI coat complex subunit beta 1
- Symbol
- copb1 Nomenclature History
- Previous Names
-
- hap
- happy
- id:ibd5034
- wu:fc66c05
- zgc:92482
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within notochord development and somite development. Predicted to be located in COPI-coated vesicle membrane and Golgi membrane. Predicted to be part of COPI vesicle coat. Is expressed in axis; brain; neural rod; and notochord. Orthologous to human COPB1 (COPI coat complex subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150894 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025944Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa3636 | unknown | Unknown | Unknown | ENU | |
| sa20952 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34079 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34080 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tc229 | unknown | Unknown | Unknown | ENU | |
| te239 | unknown | Unknown | Unknown | ENU | |
| tk56a | unknown | Unknown | Unknown | ENU | |
| tm285 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tr278 | unknown | Unknown | Unknown | ENU |
1 - 10 of 11
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Baralle-Macken syndrome | 619255 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| Domain | IPR011710 | Coatomer beta subunit, C-terminal |
| Domain | IPR029446 | Coatomer beta subunit, appendage platform domain |
| Family | IPR016460 | Coatomer beta subunit (COPB1) |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Coatomer beta subunit, appendage platform domain | Coatomer beta subunit (COPB1) | Coatomer beta subunit, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66HV4 | InterPro | 953 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-77A11 | ZFIN Curated Data | |
| Encodes | EST | fc66c05 | ZFIN Curated Data | |
| Encodes | EST | ibd5034 | ||
| Encodes | EST | IMAGE:7150894 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92482 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002013 (1) | 3239 nt | ||
| Genomic | GenBank:BX005056 (1) | 173708 nt | ||
| Polypeptide | UniProtKB:Q66HV4 (1) | 953 aa |
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yin, X., Wang, H., Zhang, Y., Dahlgren, R.A., Zhang, H., Shi, M., Gao, M., Wang, X. (2014) Toxicological Assessment of Trace β-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis. PLoS One. 9:e102731
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Harden, M.V., Newton, L.A., Lloyd, R.C., Whitlock, K.E. (2006) Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Journal of neurobiology. 66(13):1452-1466
- Coutinho, P., Parsons, M.J., Thomas, K.A., Hirst, E.M., Saude, L., Campos, I., Williams, P.H., Stemple, D.L. (2004) Differential Requirements for COPI Transport during Vertebrate Early Development. Developmental Cell. 7(4):547-558
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development (Cambridge, England). 123:103-115
1 - 10 of 11
Show