Gene
spaw
- ID
- ZDB-GENE-030219-1
- Name
- southpaw
- Symbol
- spaw Nomenclature History
- Previous Names
-
- ndr3 (2)
- unm s457
- unm t30973
- unm_s457
- unm_t30973
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within left/right pattern formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in anterior neural rod; cardiovascular system; diencephalon; mesoderm; and tail bud. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in visceral heterotaxy 5. Orthologous to human NODAL (nodal growth differentiation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 194 figures from 150 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a205 | Allele with one deletion | Exon 1 | Frameshift | CRISPR | |
| ihb889Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| s457 | Allele with one point mutation | Unknown | Start Loss | ENU | |
| sa177 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9063 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t30973 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-spaw | (2) | |
| CRISPR2-spaw | Montague et al., 2018 | |
| CRISPR3-spaw | Montague et al., 2018 | |
| CRISPR4-spaw | Zebrafish Nomenclature Committee | |
| MO1-spaw | N/A | (21) |
| MO2-spaw | N/A | (12) |
| MO3-spaw | N/A | (3) |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| anxiety disorder | zf105Tg/zf105Tg + MO1-spaw | standard conditions | Facchin et al., 2015 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZZT5 | InterPro | 404 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173B16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194178 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194213 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_180967 (1) | 1229 nt | ||
| Genomic | GenBank:CT033825 (2) | 152404 nt | ||
| Polypeptide | UniProtKB:Q7ZZT5 (1) | 404 aa |
No data available
- Buchert, R., Burkhalter, M.D., Huridou, C., Sofan, L., Roser, T., Cremer, K., Alvi, J.R., Efthymiou, S., Froukh, T., Gulieva, S., Guliyeva, U., Hamdallah, M., Holder-Espinasse, M., Kaiyrzhanov, R., Klingler, D., Koko, M., Matthies, L., Park, J., Sturm, M., Velic, A., Spranger, S., Sultan, T., Engels, H., Lerche, H., Houlden, H., Pagnamenta, A.T., Borggraefe, I., Weber, Y., Bonnen, P.E., Maroofian, R., Riess, O., Weber, J.J., Philipp, M., Haack, T.B. (2025) Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy. American journal of human genetics. :
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zhou, W., Cai, W., Li, Y., Gao, L., Liu, X., Liu, S., Lei, J., Zhang, J., Wang, Y., Jiang, Z., Wu, X., Fan, X., Li, F., Zheng, L., Yuan, W. (2025) The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. International Journal of Molecular Sciences. 26:
- Deng, Z., Ran, Q., Chang, W., Li, C., Li, B., Huang, S., Huang, J., Zhang, K., Li, Y., Liu, X., Liang, Y., Guo, Z., Huang, S. (2024) Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis. Frontiers in cell and developmental biology. 12:14297821429782
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R. (2024) ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(9):934-946
- Derrick, C.J., Szenker-Ravi, E., Santos-Ledo, A., Alqahtani, A., Yusof, A., Eley, L., Coleman, A.H.L., Tohari, S., Ng, A.Y., Venkatesh, B., Alharby, E., Mansard, L., Bonnet-Dupeyron, M.N., Roux, A.F., Vaché, C., Roume, J., Bouvagnet, P., Almontashiri, N.A.M., Henderson, D.J., Reversade, B., Chaudhry, B. (2023) Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish. Human molecular genetics. 33(2):150-169
- Nagorska, A., Zaucker, A., Lambert, F., Inman, A., Toral-Perez, S., Gorodkin, J., Wan, Y., Smutny, M., Sampath, K. (2023) Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function. Development (Cambridge, England). 150(23):
- Rochon, E.R., Xue, J., Mohammed, M.S., Smith, C., Hay-Schmidt, A., DeMartino, A.W., Clark, A., Xu, Q., Lo, C.W., Tsang, M., Tejero, J., Gladwin, M.T., Corti, P. (2023) Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. Nature communications. 14:83338333
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