Gene

spaw

ID
ZDB-GENE-030219-1
Name
southpaw
Symbol
spaw Nomenclature History
Previous Names
  • ndr3 (2)
  • unm s457
  • unm t30973
  • unm_s457
  • unm_t30973
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable cytokine activity. Acts upstream of or within left/right pattern formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in anterior neural rod; cardiovascular system; diencephalon; mesoderm; and tail bud. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in visceral heterotaxy 5. Orthologous to human NODAL (nodal growth differentiation factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
194 figures from 150 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
32 figures from 21 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a205Allele with one deletionExon 1FrameshiftCRISPR
ihb889TgTransgenic insertionExon 1UnknownDNA
s457Allele with one point mutationUnknownStart LossENU
sa177Allele with one point mutationUnknownPremature StopENU
sa9063Allele with one point mutationUnknownPremature StopENU
t30973Allele with one point mutationUnknownMissenseENU
1 - 6 of 6
Show
Sequence Targeting Reagents
1 - 7 of 7
Show
Human Disease
Associated With spaw Human Ortholog
No data available
Associated With spaw Via Experimental Models
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:Q7ZZT5 InterPro 404
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA spaw-201 (1) Ensembl 1,263 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-173B16ZFIN Curated Data
EncodescDNAMGC:194178ZFIN Curated Data
EncodescDNAMGC:194213ZFIN Curated Data
1 - 3 of 3
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
1 - 10 of 233
Show